Mortellaro C, Pucci A, Palmeri A, Lucchina A Greco, Berta M, Celeste A, Costantino S, Del Prever A Brach, Forni M
Division of Oral Maxillofacial Pathology, Department of Oral Medicine and Diagnostic Sciences, and Dental and Stomatologic Clinic of Novara, Dental School, University of Eastern Piedmont, Piazza D' Armi 1, 28100 Novara, Italy.
J Craniofac Surg. 2006 May;17(3):552-6. doi: 10.1097/00001665-200605000-00028.
Langerhans Cell Histiocytosis is a rare and protean disease of unknown etiology, clinically characterized by single or multiple osteolytic and/or soft tissue lesions. Oral involvement may predate systemic manifestations or mimic infectious/inflammatory disorders. In the present series, oral involvement characterized eight cases of pediatric Langerhans Cell Histiocytosis and oral symptoms represented a very early sign of this disease in four patients. A careful clinical investigation and a proper histologic analysis were required for achieving a definite diagnosis and for confirming clinical suspicion of disease relapse. Immunohistochemistry, that nowadays represents a reliable and accessible ancillary histological technique, allowed the definite diagnosis in all cases of our series.
