Vos F J, Bleeker-Rovers C P, Corstens F H M, Kullberg B J, Oyen W J G
Department of Internal Medicine, Nijmegen Medical Centre, Radboud University, Nijmegen, The Netherlands.
Q J Nucl Med Mol Imaging. 2006 Jun;50(2):121-30.
FDG-PET is emerging as a promising imaging technique in non-osseous infectious and inflammatory diseases, as an increasing number of reports are appearing in literature. In general, sensitivity of FDG-PET in diagnosing non-osseous infections compares favorably to other diagnostic modalities. Lower specificity due to FDG accumulation in conditions involving leukocyte activation and malignancy may be overcome by implementing FDG-PET in a diagnostic protocol. In fever of unknown origin, FDG-PET appears to be of great advantage as malignancy, inflammation and infection can be detected. Studies on standardized uptake value ratios, uptake patterns and dynamics may be helpful to increase specificity. Image fusion combining PET and CT facilitates anatomical localization of increased FDG-uptake and better guiding for further diagnostic tests to achieve a final diagnosis. More data on the utility of FDG-PET to monitor the response to treatment will be available in near future. Early reports on FDG-PET during treatment follow-up in large vessel vasculitis already showed promising
In conclusion, the body of evidence on the utility of FDG-PET in non-osseous infection and inflammation is growing and FDG-PET may become one of the preferred diagnostic procedures for these diseases.
随着文献中出现的报告越来越多，氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）在非骨感染性和炎症性疾病中正在成为一种有前景的成像技术。总体而言，FDG-PET在诊断非骨感染方面的敏感性优于其他诊断方式。在涉及白细胞激活和恶性肿瘤的情况下，由于FDG积聚导致的特异性较低，可以通过在诊断方案中采用FDG-PET来克服。在不明原因发热中，FDG-PET似乎具有很大优势，因为可以检测到恶性肿瘤、炎症和感染。关于标准化摄取值比值、摄取模式和动态变化的研究可能有助于提高特异性。将PET和CT相结合的图像融合有助于对增加的FDG摄取进行解剖定位，并为进一步的诊断测试提供更好的指导以实现最终诊断。关于FDG-PET用于监测治疗反应的更多数据将在不久的将来获得。关于大血管血管炎治疗随访期间FDG-PET的早期报告已经显示出有前景的结果：总之，关于FDG-PET在非骨感染和炎症中效用的证据正在增加，并且FDG-PET可能成为这些疾病的首选诊断程序之一。
