Turku PET Centre, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, Turku, 20521, Finland.
EJNMMI Res. 2013 Jan 3;3(1):1. doi: 10.1186/2191-219X-3-1.
The golden standard in nuclear medicine imaging of inflammation is the use of autologous radiolabeled leukocytes. Although their diagnostic accuracy is precise, the preparation of the leukocytes is both laborious and potentially hazardous for laboratory personnel. Molecules involved in leukocyte migration (homing-associated molecules) could serve as targets for the development of imaging agents for inflammation. An excellent target would be a molecule that is absent or expressed at low levels in healthy tissues, but is present or upregulated at the sites of inflammation. In this paper, we will review the literature concerning the use of homing-associated molecules as imaging targets. We will especially concentrate on vascular adhesion protein-1 due to the promising results regarding its use as a target for the imaging of inflammation.
在核医学炎症成像中，金标准是使用自体放射性标记的白细胞。尽管它们的诊断准确性非常高，但白细胞的制备既繁琐又可能对实验室人员造成危害。参与白细胞迁移的分子（归巢相关分子）可作为炎症成像剂开发的靶标。一个理想的靶标应该是一种在健康组织中不存在或表达水平低，但在炎症部位存在或上调的分子。在本文中，我们将回顾有关归巢相关分子作为成像靶标的文献。我们将特别关注血管细胞黏附分子-1，因为其作为炎症成像靶标的应用具有很大的应用前景。
