Katzmarzyk Peter T, Craig Cora L
School of Physical and Health Education, Queen's University, Kingston, ON, Canada.
Appl Physiol Nutr Metab. 2006 Jun;31(3):271-6. doi: 10.1139/h05-038.
The purpose of this study was to determine the independent effects of waist circumference (WC) and physical inactivity on the risk of mortality in women. This prospective cohort study included 5421 female participants 20-69 years of age in the 1981 Canada Fitness Survey. WC was measured with an anthropometric tape and leisure-time physical activity levels over the previous 12 months were assessed with a questionnaire. Mortality surveillance was conducted by data linkage with the Canadian Mortality Database through 31 December, 1993. The hazard ratios (HR) of mortality were estimated using Cox proportional hazards regression with age, smoking status, and alcohol consumption included as covariates in all models. A total of 225 deaths occurred over an average of 12.4 years of follow up (67 500 person-years of follow up). Physical activity (HR = 0.78; 95% C.I.: 0.64-0.95) and WC (HR = 1.17; 95% C.I.: 1.05-1.31) were associated with mortality when included in separate regression models. When included in the same model, both physical activity (HR = 0.79; 95% CI: 0.65-0.96) and WC (HR = 1.16; 95% C.I.: 1.04-1.30) remained independent significant predictors of mortality. In conclusion, physical inactivity and high WC have significant independent risks of premature mortality among women.
本研究的目的是确定腰围（WC）和缺乏身体活动对女性死亡风险的独立影响。这项前瞻性队列研究纳入了1981年加拿大健身调查中5421名年龄在20至69岁之间的女性参与者。使用人体测量带测量腰围，并通过问卷调查评估过去12个月的休闲时间身体活动水平。通过与加拿大死亡率数据库进行数据链接，对截至1993年12月31日的死亡率进行监测。在所有模型中，将年龄、吸烟状况和饮酒量作为协变量，使用Cox比例风险回归估计死亡风险比（HR）。在平均12.4年的随访期内（67500人年随访）共发生225例死亡。在单独的回归模型中，身体活动（HR = 0.78；95%置信区间：0.64 - 0.95）和腰围（HR = 1.17；95%置信区间：1.05 - 1.31）与死亡率相关。当纳入同一模型时，身体活动（HR = 0.79；95%置信区间：0.65 - 0.96）和腰围（HR = 1.16；95%置信区间：1.04 - 1.30）仍然是死亡率的独立显著预测因素。总之，缺乏身体活动和高腰围在女性中具有显著的过早死亡独立风险。
