Malpica Roxana, Sandoval Gabriela R Peña, Rodríguez Claudia, Franco Bernardo, Georgellis Dimitris
Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, México.
Antioxid Redox Signal. 2006 May-Jun;8(5-6):781-95. doi: 10.1089/ars.2006.8.781.
The Arc two-component system is a complex signal transduction system that plays a key role in regulating energy metabolism at the level of transcription in bacteria. This system comprises the ArcB protein, a tripartite membrane-associated sensor kinase, and the ArcA protein, a typical response regulator. Under anoxic growth conditions, ArcB autophosphorylates and transphosphorylates ArcA, which in turn represses or activates the expression of its target operons. Under aerobic conditions, ArcB acts as a phosphatase that catalyzes the dephosphorylation of ArcA-P and thereby releasing its transcriptional regulation. The events for Arc signaling, including signal reception and kinase regulation, signal transmission, amplification, as well as signal output and decay are discussed.
Arc双组分系统是一种复杂的信号转导系统，在细菌转录水平上调节能量代谢中起关键作用。该系统由ArcB蛋白（一种与膜相关的三方传感器激酶）和ArcA蛋白（一种典型的反应调节因子）组成。在缺氧生长条件下，ArcB进行自身磷酸化并将磷酸基团转移至ArcA，进而抑制或激活其靶操纵子的表达。在有氧条件下，ArcB作为磷酸酶催化ArcA-P的去磷酸化，从而解除其转录调控。本文讨论了Arc信号传导的过程，包括信号接收和激酶调节、信号传递、放大以及信号输出和衰减。
