Achtman M, van der Ende A, Zhu P, Koroleva I S, Kusecek B, Morelli G, Schuurman I G, Brieske N, Zurth K, Kostyukova N N, Platonov A E
Max-Planck Institut für Molekulare Genetik, Berlin, Germany.
Emerg Infect Dis. 2001 May-Jun;7(3):420-7. doi: 10.3201/eid0703.010309.
Molecular analysis of 103 serogroup A Neisseria meningitidis strains isolated in Moscow from 1969 to 1997 showed that four independent clonal groupings were responsible for successive waves of meningococcal disease. An epidemic from 1969 to the mid-1970s was caused by genocloud 2 of subgroup III, possibly imported from China. Subsequent endemic disease through the early 1990s was caused by subgroup X and then by subgroup VI, which has also caused endemic disease elsewhere in eastern Europe. A 1996 epidemic was part of the pandemic spread from Asia of genocloud 8 of subgroup III. Recent genocloud 8 epidemic disease in Moscow may represent an early warning for spread of these bacteria to other countries in Europe.
对1969年至1997年在莫斯科分离出的103株A群脑膜炎奈瑟菌进行分子分析表明,四个独立的克隆群导致了脑膜炎球菌病的连续流行浪潮。1969年至20世纪70年代中期的一次流行是由III亚组的基因群2引起的,可能是从中国传入的。随后在整个20世纪90年代初的地方病是由X亚组引起的,然后是由VI亚组引起的,VI亚组在东欧其他地方也引起了地方病。1996年的一次流行是III亚组基因群8从亚洲大流行传播的一部分。莫斯科最近的基因群8流行疾病可能是这些细菌传播到欧洲其他国家的一个早期预警。