Rigano Daniela, Grassia Armando, Borrelli Francesca, Aviello Gabriella, Piozzi Franco, Bruno Maurizio, Arnold Nelly Apostolides, Capasso Raffaele, Senatore Felice
Department of Chemistry of Natural Products, University of Naples Federico II, Naples, Italy.
Planta Med. 2006 May;72(6):575-8. doi: 10.1055/s-2006-931557.
A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.
从绵毛水苏（Marrubium globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss.，唇形科）地上部分的丙酮提取物中分离出一种新的天然半日花烷二萜——绵毛水苏苷。通过一维和二维核磁共振以及质谱等光谱方法确定了其结构。药理学研究表明，绵毛水苏提取物对角叉菜胶诱导的大鼠爪肿胀具有抗炎作用，可减轻爪部肿胀。这种活性似乎归因于绵毛水苏苷，是抑制诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）活性的结果。
