氯过氧化物酶的化合物I衍生物（一种细胞色素P450氧化剂模型）催化的双电子氧化动力学。
Kinetics of two-electron oxidations by the compound I derivative of chloroperoxidase, a model for cytochrome P450 oxidants.
作者信息
Zhang Rui, Nagraj Nandini, Lansakara-P Dharmika S P, Hager Lowell P, Newcomb Martin
机构信息
Department of Chemistry, University of Illinois at Chicago, 60607, USA.
出版信息
Org Lett. 2006 Jun 22;8(13):2731-4. doi: 10.1021/ol060762k.
Abstract
[structure: see text] Rate constants for two-electron oxidation reactions of Compound I from chloroperoxidase (CPO) with a variety of substrates were measured by stopped-flow kinetic techniques. The thiolate ligand of CPO Compound I activates the iron-oxo species with the result that oxidation reactions are 2 to 3 orders of magnitude faster than oxidations by model iron(IV)-oxo porphyrin radical cations containing weaker binding counterions.
摘要
[结构：见正文] 采用停流动力学技术测定了氯过氧化物酶（CPO）中化合物I与多种底物的双电子氧化反应的速率常数。CPO化合物I的硫醇盐配体激活了铁-氧物种，结果是氧化反应比含有较弱结合抗衡离子的模型铁（IV）-氧卟啉自由基阳离子的氧化反应快2至3个数量级。
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