[大鼠肝脏微粒体中对-450细胞色素对磺胺苯吡唑的结合及其对细胞色素-P-450还原酶的影响]
[Sulfaphenazole binding by p-450 cytochrome of liver microsomes of rats and its effect of cytochrome-p-450-reductase].
作者信息
Miuller D, Liubbe G, Khoang-Tikh K, Klinger V
出版信息
Farmakol Toksikol. 1976 May-Jun;39(3):331-2.
PMID:16775
Abstract
Tests set up "in vitro" on the rats' liver microsomes showed that sulfaphenazol, which in an inhibitor of the mixed type N-and O-demethylation, is bound as a substrate of the II type (aniline type). It attenuates spectral changes caused by aniline and vice versa. Sulfaphenazol inhibits the activity of the ADPH cytochrome-P-450-reductase.
摘要
在大鼠肝脏微粒体上进行的“体外”试验表明，作为N-和O-混合类型去甲基化抑制剂的磺胺苯唑，作为II型（苯胺型）底物被结合。它减弱了由苯胺引起的光谱变化，反之亦然。磺胺苯唑抑制ADPH细胞色素P-450还原酶的活性。
Zotero 插件