[2,6-二甲基-3,5-二乙氧羰基-1,4-二氢吡啶与大鼠肝微粒体NADP.H2特异性电子传递链酶的相互作用]
[Interaction of 2,6-dimethyl-3,5-dicarbethoxy-1,4-dihydropyridine with enzymes of the NADP.H2-specific electron transport chain of rat liver microsomes].
作者信息
Sniedze T N, Shtokman A P, Kiseleva V N, Kagen T I, Gilev A P
出版信息
Biull Eksp Biol Med. 1977 Jun;83(6):671-3.
PMID:406948
Abstract
2,6-Dimethyl-3,5-dicarboethoxy-1,4-dihydropyridine (DHP) interacts with NADPH-dependent electron transfer system of rat liver microsomes: it forms a complex with the terminal oxidase-cytochrome P-450, according to type I, and inhibits clearly the activity of NADPH-cytochromes c-reductase and mitindione dimethylesterase. DHP repeatedly administered in vivo rendered no inducing influence upon the microsomal enzymes.
摘要
2,6-二甲基-3,5-二乙氧羰基-1,4-二氢吡啶（DHP）与大鼠肝脏微粒体的NADPH依赖性电子传递系统相互作用：根据I型，它与末端氧化酶细胞色素P-450形成复合物，并明显抑制NADPH-细胞色素c还原酶和米丁二酮二甲酯酶的活性。在体内重复给予DHP对微粒体酶没有诱导作用。
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