Kayali Revasiye, Cöplü Nilay, Ceyhan Ismail, Ocak Fatih, Citil Burak Ekrem, Esen Berrin
Refik Saydam Hifzissihha Merkezi Başkanliği, Salgin Hastaliklar Araştirma Müdürlüğü, Ankara.
Mikrobiyol Bul. 2006 Jan-Apr;40(1-2):1-7.
The treatment of multidrug resistant tuberculosis (MDR-TB) requires the use of minor antituberculosis drugs, thus susceptibilities against these minor drugs should be performed. The aim of this study was to establish and standardize the susceptibility testing methods for minor antituberculosis drugs in this laboratory and to obtain data about the resistance rates. Drug susceptibility tests were performed by proportion method in Lowenstein-Jensen media for 50 MDR Mycobacterium tuberculosis isolates that have been collected from different regions of our country. Resistance rates to ethionamide, cycloserin, kanamycin, p-aminosalicylic acid, ofloxacin, thiacetasone, and capreomycin were found as 22%, 8%, 6%, 6%, 2%, 2%, and 0%, respectively. Multidrug resistance was observed in 8% of the isolates. As a result, the resistance rates of multidrug resistant M. tuberculosis strains against the tested minor antituberculosis drugs seem to be low in this study.
耐多药结核病（MDR-TB）的治疗需要使用二线抗结核药物，因此应检测对这些二线药物的敏感性。本研究的目的是在本实验室建立并标准化二线抗结核药物的药敏试验方法，并获取耐药率数据。采用比例法在罗-琴培养基上对从我国不同地区收集的50株耐多药结核分枝杆菌进行药敏试验。乙硫异烟胺、环丝氨酸、卡那霉素、对氨基水杨酸、氧氟沙星、硫乙酰胺和卷曲霉素的耐药率分别为22%、8%、6%、6%、2%、2%和0%。8%的分离株观察到耐多药。结果，本研究中耐多药结核分枝杆菌菌株对所检测的二线抗结核药物的耐药率似乎较低。
