Ergin Cağri, Kaleli Ilknur, Sahin Rasim, Ergin Seniz, Kaçar Nida
Pamukkale Universitesi Tip Fakültesi, Mikrobiyoloji Anabilim Dali, Denizli.
Mikrobiyol Bul. 2006 Jan-Apr;40(1-2):15-21.
Propionibacterium acnes is the main bacterial etiologic agent in acne vulgaris pathogenesis. The rate of antibiotic resistant P. acnes isolates is less than 10% in our country. The aim of this study was to biotype P. acnes strains which were isolated from acne vulgaris patients and to investigate the biotype distribution in our region. P. acnes isolates from 64 patients (18 male, 46 female; mean age 19 +/- 3.1 years) were included in the study and biotyped by sugar-specific pH changes using sorbitol, erythritol and ribose. Results were compared with the global acne grading scores and clinical types of the patients. The frequency rates of P. acnes biotypes were found as follows; 40 strains (62.5%) were biotype I, 3 (4.7%) were biotype II, 20 (31.3%) were biotype III and one (1.6%) was biotype IV, whereas biotype V was not detected. The acne cases who were admitted to dermatology outpatient clinics mostly complained of papulopustuler and nodulocystic lesions. Therefore the detection of antibiotic resistance rates of P. acnes strains by mass screening of the community has a growing importance. Since P. acnes biotype III is the main biotype which causes the most severe acne reactions, the 31.3% rate of frequency found in our study, can not be overlooked. As a result, this data should be considered as a guide while prescribing antibiotics for the treatment of acne patients.
痤疮丙酸杆菌是寻常痤疮发病机制中的主要细菌病原体。在我国，痤疮丙酸杆菌分离株的抗生素耐药率低于10%。本研究的目的是对从寻常痤疮患者中分离出的痤疮丙酸杆菌菌株进行生物分型，并调查我们地区的生物型分布情况。本研究纳入了64例患者（18例男性，46例女性；平均年龄19±3.1岁）的痤疮丙酸杆菌分离株，并使用山梨醇、赤藓糖醇和核糖通过糖特异性pH变化进行生物分型。将结果与患者的全球痤疮分级评分和临床类型进行比较。发现痤疮丙酸杆菌生物型的频率如下：40株（62.5%）为生物型I，3株（4.7%）为生物型II，20株（31.3%）为生物型III，1株（1.6%）为生物型IV，未检测到生物型V。皮肤科门诊收治的痤疮病例大多主诉丘疹脓疱性和结节囊肿性病变。因此，通过对社区进行大规模筛查来检测痤疮丙酸杆菌菌株的抗生素耐药率具有越来越重要的意义。由于痤疮丙酸杆菌生物型III是引起最严重痤疮反应的主要生物型，我们研究中发现的31.3%的频率不能被忽视。因此，在为痤疮患者开抗生素处方时，应将这些数据作为参考。
