Alisjahbana B, van Crevel R, Sahiratmadja E, den Heijer M, Maya A, Istriana E, Danusantoso H, Ottenhoff T H M, Nelwan R H H, van der Meer J W M
Department of Internal Medicine, Medical Faculty, Padjadjaran University, Bandung, Indonesia.
Int J Tuberc Lung Dis. 2006 Jun;10(6):696-700.
Diabetes mellitus is a known risk factor for tuberculosis (TB), but no studies have been reported from South-East Asia, which has a high burden of TB and a rapidly growing prevalence of diabetes.
To examine if and to what extent diabetes is associated with an increased risk of TB in an urban setting in Indonesia.
Case-control study comparing the prevalence of diabetes mellitus (fasting blood glucose level >126 mg/dl) among newly diagnosed pulmonary TB patients and matched neighbourhood controls.
Patients and control subjects had a similar age (median 30 years) and sex distribution (52% male), but malnutrition was more common among TB patients (median body mass index 17.7 vs. 21.5 kg/m2). HIV infection was uncommon (1.5% of patients). Diabetes mellitus was present in 60 of 454 TB patients (13.2%) and 18 of 556 (3.2%) control subjects (OR 4.7; 95%CI 2.7-8.1). Adjustment for possible confounding factors did not reduce the risk estimates. Following anti-tuberculosis treatment, hyperglycaemia reverted in a minority (3.7%) of TB patients.
Diabetes mellitus is strongly associated with TB in young and non-obese subjects in an urban setting in Indonesia. This may have implications for TB control and patient care in this region.
糖尿病是结核病的已知危险因素，但东南亚地区尚无相关研究报道，而该地区结核病负担沉重且糖尿病患病率迅速上升。
探讨在印度尼西亚城市环境中糖尿病是否以及在何种程度上与结核病风险增加相关。
病例对照研究，比较新诊断的肺结核患者与匹配的社区对照人群中糖尿病（空腹血糖水平>126mg/dl）的患病率。
患者和对照人群年龄（中位数30岁）和性别分布相似（男性占52%），但结核病患者中营养不良更为常见（中位数体重指数分别为17.7和21.5kg/m²）。HIV感染不常见（患者中占1.5%）。454例结核病患者中有60例（13.2%）患有糖尿病，556例对照人群中有18例（3.2%）患有糖尿病（比值比4.7；95%置信区间2.7 - 8.1）。对可能的混杂因素进行调整后并未降低风险估计值。抗结核治疗后，少数（3.7%）结核病患者的高血糖症状有所缓解。
在印度尼西亚城市环境中的年轻非肥胖人群中，糖尿病与结核病密切相关。这可能对该地区的结核病控制和患者护理产生影响。
