Baldé N M, Camara A, Camara L M, Diallo M M, Kaké A, Bah-Sow O Y
Service d'Endocrinologie, Hôpital Donka, CHU de Conakry, Conakry, Guinea.
Int J Tuberc Lung Dis. 2006 Sep;10(9):1036-40.
Anti-tuberculosis centres in Conakry.
To determine the prevalence of diabetes mellitus in patients with tuberculosis (TB), identify the associated risk factors and describe the clinical signs of the association of TB and diabetes.
A total of 388 patients with TB selected by simple random sampling from the register of cases diagnosed in Conakry were examined and administered a capillary blood glycaemia test to detect diabetes.
Thirteen cases of diabetes were identified, giving a prevalence rate of 3.35% (95%CI 1.35-5.35). Four (31%) had not been diagnosed before the survey. The diagnosis of diabetes preceded that of TB by an average of 5 years (range 1-9 years). The clinical characteristics of TB (frequent exposure to infection, site and proportion of new and retreated cases) did not differ from one group to another. Increased age (P < 0.0001), obesity (P < 0.005), sedentary lifestyle (P < 0.0004), and previous family history of diabetes (P = 0.04) or obesity (P = 0.04) were significantly associated with diabetes.
The prevalence of diabetes among TB patients is higher than previously estimated for Guinea. Because of frequent co-morbidity, systematic testing for diabetes among TB patients may be recommended, particularly if risk factors are present.
科纳克里的抗结核中心。
确定结核病患者中糖尿病的患病率，识别相关危险因素，并描述结核病与糖尿病合并存在时的临床症状。
从科纳克里确诊病例登记册中通过简单随机抽样选取388例结核病患者进行检查，并进行毛细血管血糖检测以检测糖尿病。
确诊13例糖尿病患者，患病率为3.35%（95%置信区间1.35 - 5.35）。4例（31%）在调查前未被诊断出患有糖尿病。糖尿病诊断比结核病诊断平均早5年（范围1 - 9年）。结核病的临床特征（频繁接触感染、新发病例和复发病例的部位及比例）在两组之间没有差异。年龄增加（P < 0.0001）、肥胖（P < 0.005）、久坐不动的生活方式（P < 0.0004）以及糖尿病家族史（P = 0.04）或肥胖家族史（P = 0.04）与糖尿病显著相关。
结核病患者中糖尿病的患病率高于几内亚此前的估计。由于合并症频繁，建议对结核病患者进行糖尿病系统检测，尤其是存在危险因素时。
