Pérez-Navarro Lucía Montserrat, Fuentes-Domínguez Francisco, Morales-Romero Jaime, Zenteno-Cuevas Roberto
Instituto de Salud Pública, Universidad Veracruzana, Xalapa, Veracruz.
Gac Med Mex. 2011 May-Jun;147(3):219-25.
In Mexico, 20% of cases of tuberculosis (TB) are associated with diabetes mellitus (DM). However, the behavior of the factors related to this comorbidity is unknown, so the aim of this study was to estimate the risk factors and outcome for TB-DM in a population from the state of Veracruz, Mexico. We developed a double-design study: cases and controls for the estimation of risk factors, and a retrospective cohort for the outcome factors. The populations surveyed were 67 patients with the comorbidity TB-DB and 109 with TB. The risk factors for tuberculosis in the diabetic population studied were: age ≥ 35 with an OR of 2.5 (95% CI: 1.4-4.3) and IMC ≥ 25 with an OR of 8.5 (95% CI: 3.1-23.3). According to the outcome variables, the patients with TB-DM showed an increased risk of 2.8 (95% CI: 2.2-3.4) for the development of drug resistance against tuberculosis. In conclusion, age and overweight are important risk factors, and drug resistance is an important outcome factor for the binomial TB-DM in the population from Veracruz. This information will have important effects on the development of surveillance programs against TB, with emphasis on the characteristics of the diabetic population.
在墨西哥，20%的结核病（TB）病例与糖尿病（DM）相关。然而，与这种合并症相关的因素的行为尚不清楚，因此本研究的目的是估计墨西哥韦拉克鲁斯州人群中结核-糖尿病的危险因素和结局。我们开展了一项双设计研究：用于估计危险因素的病例对照研究，以及用于结局因素的回顾性队列研究。调查的人群包括67例结核-糖尿病合并症患者和109例结核病患者。所研究的糖尿病患者人群中结核病的危险因素为：年龄≥35岁，比值比（OR）为2.5（95%置信区间：1.4 - 4.3）；体质指数（IMC）≥25，OR为8.5（95%置信区间：3.1 - 23.3）。根据结局变量，结核-糖尿病患者出现耐结核病的风险增加2.8倍（95%置信区间：2.2 - 3.4）。总之，年龄和超重是重要的危险因素，耐药性是韦拉克鲁斯州人群中结核-糖尿病这一二项式的重要结局因素。这些信息将对结核病监测项目的开展产生重要影响，重点关注糖尿病患者人群的特征。
