Rastas Sari, Pirttilä Tuula, Viramo Petteri, Verkkoniemi Auli, Halonen Pirjo, Juva Kati, Niinistö Leena, Mattila Kimmo, Länsimies Esko, Sulkava Raimo
Department of Neurology, Lohja Hospital, Lohja, Finland.
J Am Geriatr Soc. 2006 Jun;54(6):912-8. doi: 10.1111/j.1532-5415.2006.00742.x.
To investigate the association between blood pressure and mortality in people aged 85 and older.
Population-based prospective study with 9-year follow-up.
Department of Neuroscience and Neurology and Department of Public Health and General Practice, University of Kuopio, and Department of Clinical Neurosciences, Helsinki University Hospital.
Of all 601 people living in the city of Vantaa born before April 1, 1906, whether living at home or in institutions and alive on April 1, 1991, 521 were clinically examined and underwent blood pressure measurement.
Blood pressure was measured using a standardized method in the right arm of the subject after resting for at least 5 minutes. Information on medical history for each participant was verified from a computerized database containing all primary care health records. Death certificates were obtained from the National Register; the collection of death certificates was complete.
After adjusting for age, sex, functional status, and coexisting diseases (earlier-diagnosed myocardial infarction, congestive heart failure, dementia, cancer, stroke, or hypertension), low systolic blood pressure (BP) was associated with risk of death.
Low systolic BP may be partially related to poor general health and poor vitality, but the very old may represent a select group of individuals, and the use of BP-lowering medications needs to be evaluated in this group.
调查85岁及以上人群血压与死亡率之间的关联。
基于人群的前瞻性研究，随访9年。
库奥皮奥大学神经科学与神经病学系、公共卫生与全科医学系，以及赫尔辛基大学医院临床神经科学系。
在万塔市所有1906年4月1日前出生的601人中，无论其居住在家中还是机构中，且在1991年4月1日仍在世，对其中521人进行了临床检查并测量了血压。
在受试者至少休息5分钟后，使用标准化方法测量其右臂血压。每位参与者的病史信息从包含所有初级保健健康记录的计算机数据库中核实。死亡证明从国家登记处获取；死亡证明的收集是完整的。
在调整年龄、性别、功能状态和并存疾病（早期诊断的心肌梗死、充血性心力衰竭、痴呆、癌症、中风或高血压）后，收缩压较低与死亡风险相关。
收缩压较低可能部分与总体健康状况差和活力不足有关，但高龄人群可能是一个特殊群体，需要对该群体使用降压药物的情况进行评估。
