Sandouk Zahrae, Alirhayim Zaid, Hassan Syed, Qureshi Waqas
Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
BMJ Case Rep. 2013 Feb 20;2013:bcr2012008102. doi: 10.1136/bcr-2012-008102.
A Caucasian woman in her 60s with a history of rheumatoid arthritis presented to our institution complaining of skin ulceration. Her initial course was complicated by superinfection and sepsis until a diagnosis of cryofibrinogenaemia was finally established. Cryofibrinogenaemia remains as an under-recognised entity in part, because it can mimic other causes of skin ulcerations. In addition, its diagnosis can be challenging because of the particular handling techniques required of lab specimens. This case exemplifies some of the diagnostic and treatment challenges encountered while managing the patient with cryofibrinogenaemia.
一名60多岁有类风湿性关节炎病史的白种女性因皮肤溃疡前来我院就诊。她的初始病程因二重感染和败血症而复杂化，最终确诊为冷纤维蛋白原血症。冷纤维蛋白原血症在一定程度上仍是一个未被充分认识的疾病，因为它可能类似于皮肤溃疡的其他病因。此外，由于实验室标本需要特殊的处理技术，其诊断可能具有挑战性。本病例例证了在管理冷纤维蛋白原血症患者时遇到的一些诊断和治疗挑战。
