Shakespeare Thomas P, Gebski Val J, Thiagarajan Anuradha, Jay Lu Jiade
The Cancer Institue, Singapore.
Med Inform Internet Med. 2006 Jun;31(2):121-7. doi: 10.1080/14639230600551397.
Confidence levels, clinical significance curves and risk - benefit contours have recently been developed with the aim of improving the interpretation of clinical studies. It has been suggested that their use may complement traditional methods of result reporting (i.e. p values and 95% confidence intervals), and subsequently improve medical decision-making. These new methods have been used to report study results; however, widespread use may be hampered by the lack of available computer software. Our objective was to design user-friendly software to enable researchers to use these statistical methods.
A spreadsheet was designed to calculate these statistics for the assessment of two arm medical studies. The spreadsheet was tested using a wide range of input data and operating systems. User-friendliness was tested by researchers who had no background in statistics.
The confidence calculator was successfully designed, and found to be user-friendly. The spreadsheet is MS Excel-based to allow wide usage. The spreadsheet is freely available from the author and from the web site http://www.primercollaboration.com/Tools/tools.html.
We have successfully designed a spreadsheet that is simple to use and freely accessible for researchers. This is the first such software that calculates confidence levels, clinical significance curves, and risk - benefit contours.
置信水平、临床意义曲线和风险效益轮廓图最近已被开发出来，目的是改进对临床研究的解读。有人提出，使用这些方法可能会补充传统的结果报告方法（即p值和95%置信区间），进而改善医疗决策。这些新方法已被用于报告研究结果；然而，由于缺乏可用的计算机软件，其广泛应用可能会受到阻碍。我们的目标是设计一款用户友好的软件，使研究人员能够使用这些统计方法。
设计了一个电子表格来计算这些统计数据，以评估双臂医学研究。该电子表格使用了广泛的输入数据和操作系统进行测试。由没有统计学背景的研究人员对用户友好性进行了测试。
置信度计算器成功设计出来，并且发现其对用户友好。该电子表格基于MS Excel，以便广泛使用。该电子表格可从作者处以及网站http://www.primercollaboration.com/Tools/tools.html免费获取。
我们成功设计了一个易于使用且研究人员可免费访问的电子表格。这是首个能够计算置信水平、临床意义曲线和风险效益轮廓图的此类软件。
