Aronson Doron, Roterman Inon, Yigla Mordechay, Kerner Arthur, Avizohar Ophir, Sella Ron, Bartha Peter, Levy Yishai, Markiewicz Walter
Department of Cardiology, Rambam Medical Center, POB 9602, Haifa 31096, Israel.
Am J Respir Crit Care Med. 2006 Sep 15;174(6):626-32. doi: 10.1164/rccm.200602-243OC. Epub 2006 Jun 15.
Increased levels of systemic markers of inflammation have been reported in patients with impaired lung function due to obstructive or restrictive lung disease.
We tested the hypothesis that a decline in lung function within the normal range may be associated with a systemic subclinical inflammation.
Pulmonary function tests, cardiorespiratory fitness, components of the metabolic syndrome, and high-sensitivity C-reactive protein (CRP) were determined in 1,131 subjects without known pulmonary disease.
Ninety-six of the study participants (8.5%) had FEV(1) of less than 80% of predicted values. There was a strong inverse association between CRP levels and quartiles of FEV(1). The median CRP levels in nonsmoking participants were 2.5, 1.8, 1.7, and 1.3 mg/L in the first, second, third, and forth FEV(1) quartiles, respectively (p < 0.0001). A similar inverse association was present in smoking subjects (median CRP levels were 3.8, 2.3, 2.0, and 1.9 mg/L in the first, second, third, and fourth FEV(1) quartiles, respectively; p < 0.0001). These associations remained highly significant after adjustment for age, sex, components of the metabolic syndrome, and fitness level (p = 0.0005).
An inverse linear relationship exists between CRP concentrations and measures of pulmonary function in subjects without pulmonary disease and in never-smokers. These results indicate that systemic inflammation may be linked to early perturbations of pulmonary function.
据报道，因阻塞性或限制性肺病导致肺功能受损的患者体内炎症的全身标志物水平升高。
我们检验了以下假设，即在正常范围内肺功能下降可能与全身亚临床炎症相关。
对1131名无已知肺部疾病的受试者进行肺功能测试、心肺适能、代谢综合征组分及高敏C反应蛋白（CRP）测定。
96名研究参与者（8.5%）的第1秒用力呼气容积（FEV₁）低于预测值的80%。CRP水平与FEV₁四分位数之间存在强烈的负相关。在非吸烟参与者中，FEV₁四分位数处于第一、第二、第三和第四时，CRP中位数水平分别为2.5、1.8、1.7和1.3mg/L（p<0.0001）。吸烟受试者中也存在类似的负相关（FEV₁四分位数处于第一、第二、第三和第四时，CRP中位数水平分别为3.8、2.3、2.0和1.9mg/L；p<0.0001）。在对年龄、性别、代谢综合征组分和健康水平进行校正后，这些关联仍高度显著（p=0.0005）。
在无肺部疾病的受试者和从不吸烟者中，CRP浓度与肺功能指标之间存在负线性关系。这些结果表明全身炎症可能与肺功能的早期扰动有关。
