Hancox Robert J, Poulton Richie, Greene Justina M, Filsell Susan, McLachlan Christene R, Rasmussen Finn, Taylor D Robin, Williams Michael J A, Williamson Avis, Sears Malcolm R
Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Thorax. 2007 Dec;62(12):1064-8. doi: 10.1136/thx.2006.076877. Epub 2007 Jun 29.
Impaired lung function is associated with systemic inflammation and is a risk factor for cardiovascular disease in older adults. It is unknown when these associations emerge and to what extent they are mediated by smoking, chronic airways disease, and/or established atherosclerosis. We explored the association between the forced expiratory volume in one second (FEV(1)) and the systemic inflammatory marker C-reactive protein (CRP) in young adults.
Associations between spirometric lung function and blood CRP were assessed in a population based birth cohort of approximately 1000 New Zealanders at ages 26 and 32 years. Analyses adjusted for height and sex to account for differences in predicted lung function and excluded pregnant women.
There were significant inverse associations between FEV(1) and CRP at both ages. Similar results were found for the forced vital capacity. These associations were similar in men and women and were independent of smoking, asthma, and body mass index.
Reduced lung function is associated with systemic inflammation in young adults. This association is not related to smoking, asthma, or obesity. The reasons for the association are unexplained, but the findings indicate that the association between lower lung function and increased inflammation predates the development of either chronic lung disease or clinically significant atherosclerosis. The association between poor lung function and cardiovascular disease may be mediated by an inflammatory mechanism.
肺功能受损与全身炎症相关，是老年人患心血管疾病的危险因素。目前尚不清楚这些关联何时出现，以及它们在多大程度上由吸烟、慢性气道疾病和/或已形成的动脉粥样硬化介导。我们探讨了年轻成年人一秒用力呼气量（FEV₁）与全身炎症标志物C反应蛋白（CRP）之间的关联。
在一个基于人群的出生队列中，对约1000名26岁和32岁的新西兰人进行了肺量计肺功能与血液CRP之间关联的评估。分析对身高和性别进行了调整，以考虑预测肺功能的差异，并排除了孕妇。
在两个年龄段，FEV₁与CRP之间均存在显著的负相关。用力肺活量也有类似结果。这些关联在男性和女性中相似，且独立于吸烟、哮喘和体重指数。
肺功能下降与年轻成年人的全身炎症相关。这种关联与吸烟、哮喘或肥胖无关。关联的原因尚不清楚，但研究结果表明，肺功能降低与炎症增加之间的关联早于慢性肺病或临床显著动脉粥样硬化的发生。肺功能差与心血管疾病之间的关联可能由炎症机制介导。
