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关于金属硫蛋白的低等脊椎动物中重金属的结合与解毒作用

Binding and detoxification of heavy metals in lower vertebrates with reference to metallothionein.

作者信息

Hogstrand C, Haux C

机构信息

Department of Zoophysiology, University of Göteborg, Sweden.

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;100(1-2):137-41. doi: 10.1016/0742-8413(91)90140-o.

DOI:10.1016/0742-8413(91)90140-o
PMID:1677845
Abstract
  1. The metabolism of Cu, Zn, Cd and Hg in lower vertebrates is described, using fish as a model. 2. The main part of this review deals with metallothionein and the role of this protein for the storage and detoxification of these metals. 3. Factors influencing the bioavailability and probable uptake routes are identified. 4. The distribution of the metals within the organism is outlined. The distribution between tissues is described and the subcellular distribution discussed with reference to metallothionein.
摘要
  1. 以鱼类为模型，描述了低等脊椎动物中铜、锌、镉和汞的代谢。2. 本综述的主要部分涉及金属硫蛋白以及该蛋白在这些金属的储存和解毒中的作用。3. 确定了影响生物利用度的因素和可能的吸收途径。4. 概述了金属在生物体内的分布。描述了组织间的分布，并参照金属硫蛋白讨论了亚细胞分布。

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