脑肿瘤立体定向放射治疗后肿瘤及瘤周组织的扩散变化：治疗反应的可能预测
Diffusion changes in a tumor and peritumoral tissue after stereotactic irradiation for brain tumors: possible prediction of treatment response.
作者信息
Tomura Noriaki, Narita Komei, Izumi Jun-ichi, Suzuki Akira, Anbai Akira, Otani Takahiro, Sakuma Ikuo, Takahashi Satoshi, Mizoi Kazuo, Watarai Jiro
机构信息
Department of Radiology, Akita University School of Medicine, and Department of Radiology, Akita University Hospital, Japan.
出版信息
J Comput Assist Tomogr. 2006 May-Jun;30(3):496-500. doi: 10.1097/00004728-200605000-00024.
OBJECTIVE
Changes in apparent diffusion coefficient (ADC) in a tumor and peritumoral tissue after stereotactic irradiation (STI) were evaluated, and then the therapeutic efficacy of ADC measurement was assessed.
METHODS
In 20 tumors, diffusion-weighted imaging within 1 week before and 2-4 weeks after STI was performed. The normalized ADC (nADC) was measured. The nADCs in the tumor and peritumoral region before STI were compared with those after STI and the change in tumor nADC compared with the change in tumor size.
RESULTS
The nADC of the tumors was significantly higher 2-4 weeks after STI compared with that before STI. The nADC of the peritumoral regions 2-4 weeks after STI did not differ significantly from that before STI. A significant difference in the nADC at 2-4 weeks after STI was observed between the responder and nonresponder groups.
CONCLUSIONS
Changes in nADC as measured by diffusion-weighted imaging can predict response to STI.
目的
评估立体定向放射治疗（STI）后肿瘤及瘤周组织表观扩散系数（ADC）的变化，进而评估ADC测量的治疗效果。
方法
对20例肿瘤患者在STI前1周内及STI后2 - 4周进行扩散加权成像。测量标准化ADC（nADC）。比较STI前肿瘤及瘤周区域的nADC与STI后的nADC，并比较肿瘤nADC的变化与肿瘤大小的变化。
结果
与STI前相比，STI后2 - 4周肿瘤的nADC显著升高。STI后2 - 4周瘤周区域的nADC与STI前相比无显著差异。在反应者和无反应者组之间观察到STI后2 - 4周nADC存在显著差异。
结论
通过扩散加权成像测量的nADC变化可预测对STI的反应。
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