从鼠到人与人体解剖结构的对应关系
Of mice and men: aligning mouse and human anatomies.
作者信息
Bodenreider Olivier, Hayamizu Terry F, Ringwald Martin, De Coronado Sherri, Zhang Songmao
机构信息
National Library of Medicine, Bethesda, USA.
出版信息
AMIA Annu Symp Proc. 2005;2005:61-5.
This paper reports on the alignment between mouse and human anatomies, a critical resource for comparative science as diseases in mice are used as mod-els of human disease. The two ontologies under investigation are the NCI Thesaurus (human anatomy) and the Adult Mouse Anatomical Dictionary, each comprising about 2500 anatomical concepts. This study compares two approaches to aligning ontologies. One is fully automatic, based on a combination of lexical and structural similarity; the other is manual. The resulting mappings were evaluated by an expert. 715 and 781 mappings were identified by each method respectively, of which 639 are common to both and all valid. The applications of the map-ping are discussed from the perspective of biology and from that of ontology.
本文报道了小鼠与人体解剖结构的比对情况，这是比较科学的一项关键资源，因为小鼠疾病被用作人类疾病的模型。所研究的两种本体分别是美国国立癌症研究所术语表（人体解剖学）和成年小鼠解剖学词典，每种都包含约2500个解剖学概念。本研究比较了两种本体比对方法。一种是基于词汇和结构相似性组合的全自动方法；另一种是人工方法。由一位专家对所得映射进行评估。两种方法分别识别出715个和781个映射，其中639个是两者共有的且全部有效。从生物学和本体论的角度讨论了该映射的应用。
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