凝血因子 XIII 替代疗法：溃疡性结肠炎的一种治疗方法。
Substitution of factor XIII: a therapeutic approach to ulcerative colitis.
作者信息
Lorenz R, Heinmüller M, Classen M, Tornieporth N, Gain T
机构信息
II. Medizinische Klinik und Poliklinik, Technischen Universität München, FRG.
出版信息
Haemostasis. 1991;21(1):5-9. doi: 10.1159/000216195.
Three patients with ulcerative colitis in the active stage demonstrated reduced levels of F XIII activity and F XIII subunit A (61 and 80.3%, respectively). Because of the lack of clinical improvement during conservative therapy, the patients were treated additionally with F XIII concentrate (Fibrogammin HS, Behring, FRG) for 10 days. The substitution resulted in an increase in F XIII activity (144.3%) and F XIII subunit A (238%) as well as in a marked improvement in symptoms.
三名处于活动期的溃疡性结肠炎患者的纤维蛋白原 XIII 活性和纤维蛋白原 XIII A 亚基水平降低（分别为 61% 和 80.3%）。由于保守治疗期间临床症状未改善，这些患者额外接受了纤维蛋白原 XIII 浓缩物（Fibrogammin HS，德国贝林公司）治疗 10 天。替代治疗导致纤维蛋白原 XIII 活性增加（144.3%）和纤维蛋白原 XIII A 亚基增加（238%），症状也有显著改善。
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