Jain Kewal K
Jain PharmaBiotech, Basel, Switzerland.
Drug Discov Today. 2005 Nov 1;10(21):1435-42. doi: 10.1016/S1359-6446(05)03573-7.
The application of nanotechnology in life sciences, nanobiotechnology, is already having an impact on diagnostics and drug delivery. Now, researchers are starting to use nanotechnology in the field of drug discovery. This review explains how several technologies, including nanoparticles and nanodevices such as nanobiosensors and nanobiochips, are used to improve drug discovery and development. Nanoscale assays can contribute significantly to cost-saving in screening campaigns. In addition, some nanosubstances (such as fullerenes) could be potential drugs for the future. Although there might be some safety concerns with respect to the in vivo use of nanoparticles, studies are in place to determine the nature and extent of adverse events. Future prospects for the application of nanotechnology in healthcare and for the development of personalized medicine appear to be excellent.
纳米技术在生命科学中的应用,即纳米生物技术,已经对诊断和药物递送产生了影响。如今,研究人员开始在药物发现领域使用纳米技术。这篇综述解释了包括纳米颗粒以及诸如纳米生物传感器和纳米生物芯片等纳米器件在内的几种技术是如何用于改进药物发现和开发的。纳米级分析可以在筛选活动中显著节省成本。此外,一些纳米物质(如富勒烯)可能会成为未来的潜在药物。尽管纳米颗粒的体内使用可能存在一些安全问题,但已有研究来确定不良事件的性质和程度。纳米技术在医疗保健中的应用以及个性化医疗的发展前景似乎十分广阔。