Wu S L, Chu Paul K, Liu X M, Chung C Y, Ho J P Y, Chu C L, Tjong S C, Yeung K W K, Lu W W, Cheung K M C, Luk K D K
Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong.
J Biomed Mater Res A. 2006 Oct;79(1):139-46. doi: 10.1002/jbm.a.30705.
Good surface properties and biocompatibility are crucial to porous NiTi shape memory alloys (SMA) used in medical implants, as possible nickel release from porous NiTi may cause deleterious effects in the human body. In this work, oxygen plasma immersion ion implantation (O-PIII) was used to reduce the amount of nickel leached from porous NiTi alloys with a porosity of 42% prepared by capsule-free hot isostatic pressing. The mechanical properties, surface properties, and biocompatibility were studied by compression tests, X-ray photoelectron spectroscopy (XPS), and cell culturing. The O-PIII porous NiTi SMAs have good mechanical properties and excellent superelasticity, and the amount of nickel leached from the O-PIII porous NiTi is much less than that from the untreated samples. XPS results indicate that a nickel-depleted surface layer predominantly composed of TiO(2) is produced by O-PIII and acts as a barrier against out-diffusion of nickel. The cell culturing tests reveal that both the O-PIII and untreated porous NiTi alloys have good biocompatibility.
良好的表面性能和生物相容性对于用于医疗植入物的多孔镍钛形状记忆合金（SMA）至关重要，因为多孔镍钛合金中可能释放的镍会对人体产生有害影响。在这项工作中，采用氧等离子体浸没离子注入（O-PIII）来减少通过无包套热等静压制备的孔隙率为42%的多孔镍钛合金的镍浸出量。通过压缩试验、X射线光电子能谱（XPS）和细胞培养研究了其力学性能、表面性能和生物相容性。经O-PIII处理的多孔镍钛形状记忆合金具有良好的力学性能和优异的超弹性，且经O-PIII处理的多孔镍钛合金的镍浸出量远低于未处理样品。XPS结果表明，O-PIII处理产生了主要由TiO(2)组成的贫镍表面层，该表面层起到了阻止镍向外扩散的屏障作用。细胞培养试验表明，经O-PIII处理和未处理的多孔镍钛合金均具有良好的生物相容性。
