Edwin Francis, Wiepz Gregory J, Singh Rakesh, Peet Chimera Rene, Chaturvedi Deepti, Bertics Paul J, Patel Tarun B
Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Maywood, IL, USA.
Methods Mol Biol. 2006;327:1-24. doi: 10.1385/1-59745-012-x:1.
Since the isolation of epidermal growth factor (EGF) from mouse submaxillary glands in the early 1950s by Cohen and coworkers, this growth factor has been shown to have various effects on numerous cellular systems. The biological and physiological role that EGF plays during development and in adult animals led to the identification of its receptor (EGFR) as well as the other members of the EGF family of growth factors and their receptors. In this chapter we provide a historical overview of the discovery of EGF, identification of the other members of EGF family, early studies on the actions of EGF, as well as the discovery and structural characterization of its receptor. Further, we have reviewed the transactivation of the EGFR by agonists for G protein-coupled receptors (GPCRs) and other extracellular stimuli unrelated to EGF-like ligands. Finally, an overview of the role of the EGFR family members in various diseases, including different forms of cancer, is provided.
自20世纪50年代初科恩及其同事从小鼠颌下腺中分离出表皮生长因子（EGF）以来，已证明这种生长因子对众多细胞系统具有多种作用。EGF在发育过程中和成年动物体内所起的生物学和生理学作用，促使其受体（EGFR）以及EGF生长因子家族的其他成员及其受体得以鉴定。在本章中，我们将对EGF的发现、EGF家族其他成员的鉴定、EGF作用的早期研究以及其受体的发现和结构特征进行历史概述。此外，我们还综述了G蛋白偶联受体（GPCR）激动剂及其他与EGF样配体无关的细胞外刺激对EGFR的反式激活作用。最后，概述了EGFR家族成员在包括不同形式癌症在内的各种疾病中的作用。
