Prenzel N, Zwick E, Leserer M, Ullrich A
Max-Planck Institut für Biochemie, Department of Molecular Biology, Martinsried, Germany.
Breast Cancer Res. 2000;2(3):184-90. doi: 10.1186/bcr52. Epub 2000 Mar 25.
Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has been identified as a key element in the complex signalling network that is utilized by various classes of cell-surface receptors. This nonclassical mode of signalling system cross-talk, in distinction to receptor activation induced by cognate ligands, has been termed 'signal transactivation'. With the EGFR as the convergence point and distribution focus, this scenario may involve signals emitted by other members of the tyrosine kinase family, cytokine receptors, ion channels, G-protein-coupled receptors and integrins.
不同信号系统之间的交叉通讯对于整合多种不断变化的环境对单个细胞的影响至关重要。表皮生长因子受体（EGFR）已被确定为各类细胞表面受体所利用的复杂信号网络中的关键元件。与同源配体诱导的受体激活不同，这种信号系统串扰的非经典模式被称为“信号转激活”。以EGFR作为汇聚点和分布焦点，这种情况可能涉及酪氨酸激酶家族的其他成员、细胞因子受体、离子通道、G蛋白偶联受体和整合素发出的信号。
