Przepiera-Bedzak Hanna, Peregud-Pogorzelska Małgorzata, Brzosko Marek, Brzosko Iwona, Płońska Edyta, Kornacewicz-Jach Zdzisława
Klinika Reumatologii, Pomorska Akademia Medyczna, Szczecin.
Pol Merkur Lekarski. 2006 Mar;20(117):296-8.
Cardiovascular involvement in the course of ankylosing spondylitis (AS) is a very important problem. The aim was to assess the influence of the activity of the disease on echocardiographic abnormalities in ankylosing spondylitis.
We studied 38 AS patients. Activity of the disease was assessed according to the ESR and following indexes: BASMI, BASFI, BASDAI, BASG-t, BASG-6. Using 2-dimensional echo Doppler (Acuson 128XP) the heart dimensions were determined according to the American Society of Echocardiography guidelines.
Patients with mitral valve prolapse compared with the group of the AS patients without this abnormality had significant higher (p = 0.05) activity of the disease assessed by ESR. Patients with aortic incompetence compared with the group of the AS patients without this abnormality, had significant (p = 0.04) lower disease activity assessed by BASG-6. We found significant negative correlation between EF and disease duration, and significant lower disease activity assessed by BA SG-6. Patients with pericardial effusion compared with group without this had significant shorter (p = 0.05) disease duration.
There was no significant influence of the following indexes: BASMI, BASFI, BASDAI, BASG-t, BASG-6 of the activity of the disease on echocardiographic abnormalities in ankylosing spondylitis.
强直性脊柱炎（AS）病程中的心血管受累是一个非常重要的问题。目的是评估疾病活动度对强直性脊柱炎患者超声心动图异常的影响。
我们研究了38例AS患者。根据血沉（ESR）以及以下指标评估疾病活动度：BASMI、BASFI、BASDAI、BASG - t、BASG - 6。使用二维超声多普勒（Acuson 128XP），根据美国超声心动图学会指南测定心脏尺寸。
与无二尖瓣脱垂的AS患者组相比，二尖瓣脱垂患者经ESR评估的疾病活动度显著更高（p = 0.05）。与无主动脉瓣关闭不全的AS患者组相比，主动脉瓣关闭不全患者经BASG - 6评估的疾病活动度显著更低（p = 0.04）。我们发现射血分数（EF）与病程之间存在显著负相关，且经BASG - 6评估的疾病活动度显著更低。与无心包积液的患者组相比，有心包积液的患者病程显著更短（p = 0.05）。
疾病活动度的以下指标：BASMI、BASFI、BASDAI、BASG - t、BASG - 6对强直性脊柱炎患者的超声心动图异常无显著影响。
