O'Neill T W, King G, Graham I M, Molony J, Bresnihan B
Department of Rheumatology, St Vincents Hospital, Dublin, Ireland.
Ann Rheum Dis. 1992 May;51(5):652-4. doi: 10.1136/ard.51.5.652.
Twenty four patients with ankylosing spondylitis of 10 or more years' duration were assessed for evidence of cardiac disease. Seven patients (29%) had evidence of cardiac disease, including one patient with a pericardial effusion, three with conduction abnormalities, and two with aortic incompetence. Aortic incompetence in one patient was clinically silent and was detected only with Doppler echocardiography. This patient had, in addition, thickening of the posterior aortic wall, an echocardiographic feature not previously described in ankylosing spondylitis. There was no evidence of aortic valve disease in a control group matched for age and sex. Patients with ankylosing spondylitis and cardiac abnormalities were older, had a longer disease duration, and more peripheral joint disease than those without cardiac abnormalities. Doppler echocardiography is a useful technique in the assessment of cardiac disease in ankylosing spondylitis and may detect aortic valve disease at an early preclinical stage.
对24例病程达10年及以上的强直性脊柱炎患者进行了心脏疾病证据评估。7例患者（29%）有心脏疾病证据，包括1例心包积液患者、3例传导异常患者和2例主动脉瓣关闭不全患者。1例患者的主动脉瓣关闭不全在临床上无症状，仅通过多普勒超声心动图检测到。此外，该患者主动脉后壁增厚，这是强直性脊柱炎中以前未描述过的超声心动图特征。在年龄和性别匹配的对照组中没有主动脉瓣疾病的证据。与无心脏异常的患者相比，有心脏异常的强直性脊柱炎患者年龄更大、病程更长且外周关节疾病更多。多普勒超声心动图是评估强直性脊柱炎患者心脏疾病的有用技术，可能在临床前期早期检测到主动脉瓣疾病。
