Shanmuganayagam Dhanansayan, Warner Thomas F, Krueger Christian G, Reed Jess D, Folts John D
Department of Medicine, Section of Cardiovascular Medicine, University of Wisconsin, Madison, WI 53792, United States.
Atherosclerosis. 2007 Jan;190(1):135-42. doi: 10.1016/j.atherosclerosis.2006.03.017. Epub 2006 Jun 14.
Intake of Concord grape juice (CGJ), rich in polyphenolics, inhibits platelet aggregation (PA), a risk factor for cardiovascular disease (CVD), in normocholesterolemic animals and humans. It is unclear whether CGJ can attenuate hypercholesterolemia-enhanced PA. The effects of daily CGJ consumption on hypercholesterolemia-enhanced PA and the development of atherosclerosis were investigated. Two groups of rabbits (Control and Treated; n=10 each) were fed a hypercholesterolemic diet for 48 days. Treated group then received supplemental CGJ (225mL/day) while Control group received supplemental iso-caloric sugar water for 48 days. Collagen-, collagen+epinephrine- and phorbol-12-myristate-13-acetate-induced whole blood PA responses were measured on Days 0, 48 and 96; total serum cholesterol and blood pressure were also measured. The development of aortic atheroma was quantified at the end. Both groups showed significant increases in PA and serum cholesterol at Day 48. However, at Day 96, Treated group showed significantly lower PA and development of atheroma (30.7+/-3.9% lower (p<0.001)) than Control group; Treated group also had significantly lower total serum cholesterol and blood pressure than Control group. In conclusion, daily consumption of CGJ attenuates hypercholesterolemia-enhanced PA, blood pressure, total serum cholesterol and development of atheroma in rabbits.
摄入富含多酚类物质的康科德葡萄汁（CGJ）可抑制血小板聚集（PA），而血小板聚集是心血管疾病（CVD）的一个风险因素，在正常胆固醇水平的动物和人类中均如此。目前尚不清楚CGJ是否能减轻高胆固醇血症增强的血小板聚集。本研究调查了每日饮用CGJ对高胆固醇血症增强的血小板聚集及动脉粥样硬化发展的影响。将两组兔子（对照组和治疗组；每组n = 10）喂食高胆固醇饮食48天。治疗组随后接受补充CGJ（225mL/天），而对照组接受补充等热量糖水，持续48天。在第0、48和96天测量胶原、胶原+肾上腺素和佛波醇-12-肉豆蔻酸酯-13-乙酸酯诱导的全血血小板聚集反应；还测量了总血清胆固醇和血压。最后对主动脉粥样硬化的发展进行量化。两组在第48天时血小板聚集和血清胆固醇均显著升高。然而，在第96天时，治疗组的血小板聚集和动脉粥样硬化发展（降低30.7±3.9%（p<0.001））显著低于对照组；治疗组的总血清胆固醇和血压也显著低于对照组。总之，每日饮用CGJ可减轻高胆固醇血症增强的血小板聚集、血压、总血清胆固醇以及兔子动脉粥样硬化的发展。
