在微波辐射下，将芳基支架环合到 A/B-环甾体的一种方便策略。
A convenient strategy for the annulation of aryl scaffold to A/B-ring steroids under microwave irradiation.
机构信息
Medicinal Chemistry Division, North-East Institute of Science and Technology (CSIR), Jorhat, Assam 785006, India.
出版信息
Steroids. 2010 Jun;75(6):445-9. doi: 10.1016/j.steroids.2010.02.009. Epub 2010 Feb 21.
Abstract
A facile strategy for the annulation of 2,6-dicyanoaniline moiety to steroidal A/B-ring is described from base catalyzed and microwave-promoted reaction of steroidal 3-keto-2-hydroxymethylenes with malononitrile in high yields. The generality of the reaction has been extended to non-steroidal cyclic and aliphatic ketohydroxylmethylenes.
摘要
描述了一种简便的策略，通过甾体 3-酮-2-羟亚甲基与丙二腈在碱催化和微波促进下的反应，将 2,6-二氰基苯胺部分环合到甾体 A/B 环上，产率很高。该反应的通用性已扩展到非甾体环状和脂肪族酮羟亚甲基。
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