Missaoui B, Revel M
Service de Rééducation et de Réadaptation de l'Appareil Locomoteur et des Pathologies du Rachis, Faculté de Médecine, Université René-Descartes, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, France.
Ann Readapt Med Phys. 2006 Jul;49(6):305-8, 389-91. doi: 10.1016/j.annrmp.2006.03.007. Epub 2006 Apr 19.
To review the literature on fatigue in ankylosing spondylitis (AS), the tools of its measurement, relation with the other parameters of the disease, treatment and its relation with exercises.
Medline, Embase, Pascal and Cochrane library databases were searched with the keywords fatigue, spondyloarthropathy, ankylosing spondylitis, evaluation, assessment, outcome, exercise, and rehabilitation. A total of 21 papers were reviewed.
Fatigue is a frequent complaint of patients with AS. It is assessed mainly on a visual analog scale and is one of the parameters of the disease activity index Bath Ankylosing Spondylitis Disease Activity Index BASDAI. Fatigue has a strong relation with the other symptoms of AS (stiffness and pain). It is negatively influenced by sleep disorders. Quality of life of these patients is considerably reduced. Anti-TNF therapy seem to ameliorate fatigue more than nonsteroidal anti-inflammatory drug therapy. Regular physical activity is recommended to help alleviate the fatigue.
No valid, relevant composite tool of multidimensional and multifactorial characters exists to assess fatigue in AS. Treatment such as anti-TNF therapy may facilitate rehabilitation. Regular physical activity helps alleviate fatigue and improves quality of life.
回顾关于强直性脊柱炎（AS）疲劳的文献、其测量工具、与疾病其他参数的关系、治疗及其与运动的关系。
使用关键词疲劳、脊柱关节病、强直性脊柱炎、评估、评价、结果、运动和康复检索Medline、Embase、Pascal和Cochrane图书馆数据库。共回顾了21篇论文。
疲劳是AS患者常见的主诉。主要通过视觉模拟量表进行评估，是疾病活动指数巴斯强直性脊柱炎疾病活动指数（BASDAI）的参数之一。疲劳与AS的其他症状（僵硬和疼痛）密切相关。它受到睡眠障碍的负面影响。这些患者的生活质量大幅降低。抗TNF治疗似乎比非甾体抗炎药治疗更能改善疲劳。建议进行规律的体育活动以帮助减轻疲劳。
不存在有效的、相关的多维多因素综合工具来评估AS中的疲劳。抗TNF治疗等治疗可能有助于康复。规律的体育活动有助于减轻疲劳并改善生活质量。
