Tang Oi Shan, Ho Pak Chung
Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, People's Republic of China.
Contraception. 2006 Jul;74(1):26-30. doi: 10.1016/j.contraception.2006.03.005. Epub 2006 Apr 27.
Misoprostol is a synthetic prostaglandin E(1) analogue that is commonly used for medical abortion. It can be given orally, vaginally and sublingually. A pharmacokinetic study has shown that sublingual misoprostol has the shortest onset of action, the highest peak concentration and the greatest bioavailability among the three routes of administration. Earlier clinical trials have shown that vaginal misoprostol is superior to oral misoprostol when combined with mifepristone for early first-trimester medical abortion. Recent studies on the clinical efficacy of sublingual misoprostol have demonstrated that it is as effective as vaginal misoprostol. Further studies are required to determine the optimal dose and route of administration of misoprostol that can give the highest complete abortion rate, lowest ongoing pregnancy rate and least side effects.
米索前列醇是一种合成的前列腺素E(1)类似物，常用于药物流产。它可以口服、经阴道和舌下给药。一项药代动力学研究表明，在三种给药途径中，舌下含服米索前列醇的起效时间最短、峰值浓度最高且生物利用度最大。早期临床试验表明，在与米非司酮联合用于孕早期药物流产时，经阴道给予米索前列醇优于口服米索前列醇。近期关于舌下含服米索前列醇临床疗效的研究表明，其效果与经阴道给予米索前列醇相同。需要进一步研究以确定能实现最高完全流产率、最低持续妊娠率和最少副作用的米索前列醇最佳剂量和给药途径。
