Grajewski A L, Ferrari-Dileo G, Feuer W J, Anderson D R
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, FL 33101.
Ophthalmology. 1991 Jun;98(6):989-95. doi: 10.1016/s0161-6420(91)32216-4.
Using in vitro binding methods and autoradiographs, the authors showed that choroidal vessels specifically bind iodine 125 cyanopindolol, a nonselective blocker of beta-adrenergic receptors, in albino rabbits. In humans, the presence of beta-adrenergic receptors in choroidal vessels was confirmed by showing an increased choroidal vascular tone after systemic administration of timolol maleate, a nonselective beta-adrenergic blocker. Topically administered timolol maleate lowered the intraocular pressure but did not reach the choroidal receptors in sufficient quantity to produce a measurable effect on vascular tone.
作者使用体外结合方法和放射自显影片显示，在白化兔中，脉络膜血管特异性结合碘125氰吲哚洛尔，这是一种β-肾上腺素能受体的非选择性阻滞剂。在人类中，通过给予马来酸噻吗洛尔（一种非选择性β-肾上腺素能阻滞剂）全身给药后脉络膜血管张力增加，证实了脉络膜血管中存在β-肾上腺素能受体。局部应用马来酸噻吗洛尔可降低眼压，但未足量到达脉络膜受体以对血管张力产生可测量的影响。
