Budson Andrew E, Todman Raleigh W, Chong Hyemi, Adams Eleanor H, Kensinger Elizabeth A, Krangel Terri S, Wright Christopher I
Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA 01730, USA.
Cogn Behav Neurol. 2006 Jun;19(2):71-8. doi: 10.1097/01.wnn.0000213905.49525.d0.
To examine 3 different aspects of the emotional memory effect in aging and Alzheimer disease (AD): item-specific recollection, gist memory, and recognition response bias.
Younger adults, older adults, and patients with AD performed a false recognition memory test in which participants were tested on "lure" items that were not seen at study, but were semantically related to the study items. Participants were tested on 5 emotional and 5 non-emotional lists.
In addition to finding an increase in true recognition for emotional versus non-emotional items in healthy younger and older adults but not in patients with AD, and confirming that emotional items led younger adults to shift their response bias to a more liberal one, 3 novel findings were observed. First, the emotional effect on response bias was also observed in healthy older adults. Second, the opposite emotional effect on response bias was observed in patients with AD. Third, emotional items did not lead to an improvement in item-specific recollection or gist memory.
Although healthy older adults show the normal amygdala-modulated criterion shift for emotional items-influencing their subjective feeling that information has been previously encountered, the amygdala pathology present in early AD may disrupt this influence.
研究衰老和阿尔茨海默病（AD）中情绪记忆效应的3个不同方面：特定项目回忆、要点记忆和识别反应偏差。
年轻成年人、年长成年人和AD患者进行了一项错误识别记忆测试，其中参与者接受对在学习时未见过但在语义上与学习项目相关的“诱饵”项目的测试。参与者在5个情绪列表和5个非情绪列表上接受测试。
除了发现健康的年轻和年长成年人对情绪项目的正确识别相对于非情绪项目增加，而AD患者没有增加，并证实情绪项目导致年轻成年人将他们的反应偏差转向更宽松的偏差外，还观察到3个新发现。第一，在健康的年长成年人中也观察到情绪对反应偏差的影响。第二，在AD患者中观察到对反应偏差相反的情绪影响。第三，情绪项目没有导致特定项目回忆或要点记忆的改善。
尽管健康的年长成年人对情绪项目表现出正常的杏仁核调节的标准转移——影响他们对信息先前已遇到的主观感觉，但早期AD中存在的杏仁核病理学可能会破坏这种影响。
