LaBar Kevin S, Torpey Dana C, Cook Craig A, Johnson Stephanie R, Warren Lauren H, Burke James R, Welsh-Bohmer Kathleen A
Center for Cognitive Neuroscience, Duke University Box 90999, Durham, NC 27708-0999, USA.
Neuropsychologia. 2005;43(12):1824-37. doi: 10.1016/j.neuropsychologia.2005.01.018. Epub 2005 Feb 25.
Perceptual priming for emotionally-negative and neutral scenes was tested in early-stage Alzheimer's disease (AD) patients and healthy younger, middle-aged and older adults. In the study phase, participants rated the scenes for their arousal properties. In the test phase, studied and novel scenes were initially presented subliminally, and the exposure duration was gradually increased until a valence categorization was made. The difference in exposure duration required to categorize novel versus studied items was the dependent measure of priming. Aversive content increased the magnitude of priming, an effect that was preserved in healthy aging and AD. Results from an immediate recognition memory test showed that the priming effects could not be attributable to enhanced explicit memory for the aversive scenes. These findings implicate a dissociation between the modulatory effect of emotion across implicit and explicit forms of memory in aging and early-stage AD.
在早期阿尔茨海默病（AD）患者以及健康的年轻人、中年人和老年人中，对情绪消极和中性场景的知觉启动进行了测试。在研究阶段，参与者对场景的唤醒特性进行评分。在测试阶段，最初以阈下方式呈现已研究过的和新的场景，且曝光持续时间逐渐增加，直到做出效价分类。对新物品与已研究物品进行分类所需的曝光持续时间差异是启动的相关测量指标。厌恶内容增加了启动的幅度，这一效应在健康老龄化和AD中均存在。即时识别记忆测试的结果表明，启动效应并非归因于对厌恶场景的显性记忆增强。这些发现表明，在衰老和早期AD中，情绪在隐性和显性记忆形式中的调节作用存在分离。
