烟酰胺磷酸核糖转移酶/前B细胞克隆增强因子/内脂素（Nampt/PBEF/visfatin）的结构，一种哺乳动物烟酰胺腺嘌呤二核苷酸（NAD+）生物合成酶。
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.
作者信息
Wang Tao, Zhang Xiangbin, Bheda Poonam, Revollo Javier R, Imai Shin-ichiro, Wolberger Cynthia
机构信息
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, Maryland 21205, USA.
出版信息
Nat Struct Mol Biol. 2006 Jul;13(7):661-2. doi: 10.1038/nsmb1114. Epub 2006 Jun 18.
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
烟酰胺磷酸核糖转移酶（Nampt）在哺乳动物烟酰胺腺嘌呤二核苷酸（NAD+）生物合成途径中，由烟酰胺合成烟酰胺单核苷酸（NMN），并且在体内是沉默信息调节因子1（SirT1）活性所必需的。Nampt也被认为是一种细胞因子（前B细胞克隆增强因子，PBEF）或一种激素（内脂素，visfatin）。有或没有NMN存在时Nampt的晶体结构表明，Nampt是一种二聚体II型磷酸核糖转移酶，并为其酶促机制提供了见解。
Zotero 插件