Boutlis Craig S, Yeo Tsin W, Anstey Nicholas M
Division of Tropical and Emerging Infectious Diseases, Menzies School of Health Research, Charles Darwin University, PO Box 41096, Casuarina, NT 0811, Australia.
Trends Parasitol. 2006 Aug;22(8):371-7. doi: 10.1016/j.pt.2006.06.002. Epub 2006 Jun 19.
How is it that individuals exposed to intense malaria transmission can tolerate the presence of malaria parasites in their blood at levels that would produce fever in others? In light of evidence discounting a role for nitric oxide or antibodies to plasmodial glycosylphosphatidylinositols in maintaining this tolerant state, refractoriness to toxin-induced Toll-like receptor-mediated signalling has emerged as a likely explanation that links malarial and bacterial endotoxin tolerance. Understanding the mechanisms underlying tolerance and the potential for cross-tolerization has significant implications for understanding the potential for antitoxic vaccine strategies, as well as interactions between different malaria species and between malaria and other human parasites.
暴露于高强度疟疾传播环境中的个体，是如何能够耐受其血液中疟原虫的存在，而这些疟原虫数量若在其他人身上则会引发发烧呢？鉴于有证据表明一氧化氮或抗疟原虫糖基磷脂酰肌醇抗体在维持这种耐受状态中不起作用，对毒素诱导的Toll样受体介导信号传导的难治性已成为一种可能的解释，它将疟疾耐受与细菌内毒素耐受联系起来。了解耐受背后的机制以及交叉耐受的可能性，对于理解抗毒素疫苗策略的潜力，以及不同疟原虫物种之间以及疟疾与其他人体寄生虫之间的相互作用具有重要意义。
