Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Department of Epidemiology of Parasitic Diseases, International Center of Excellence in Research, Malaria Research and Training Centre, University of Sciences, Technique and Technology of Bamako, Bamako, Mali.
Scand J Immunol. 2020 Oct;92(4):e12932. doi: 10.1111/sji.12932.
There are an estimated over 200 million yearly cases of malaria worldwide. Despite concerted international effort to combat the disease, it still causes approximately half a million deaths every year, the majority of which are young children with Plasmodium falciparum infection in sub-Saharan Africa. Successes are largely attributed to malaria prevention strategies, such as insecticide-treated mosquito nets and indoor spraying, as well as improved access to existing treatments. One important hurdle to new approaches for the treatment and prevention of malaria is our limited understanding of the biology of Plasmodium infection and its complex interaction with the immune system of its human host. Therefore, the elimination of malaria in Africa not only relies on existing tools to reduce malaria burden, but also requires fundamental research to develop innovative approaches. Here, we summarize our discoveries from investigations of ethnic groups of West Africa who have different susceptibility to malaria.
据估计，全球每年有超过 2 亿例疟疾病例。尽管国际社会齐心协力对抗这种疾病，但它每年仍导致约 50 万人死亡，其中大多数是感染恶性疟原虫的撒哈拉以南非洲地区的幼儿。成功主要归因于疟疾预防策略，例如使用杀虫剂处理过的蚊帐和室内喷洒，以及改善对现有治疗方法的获取。新的疟疾治疗和预防方法面临的一个重要障碍是我们对疟原虫感染的生物学及其与人类宿主免疫系统的复杂相互作用的理解有限。因此，在非洲消除疟疾不仅依赖于减少疟疾负担的现有工具，还需要开展基础研究以开发创新方法。在这里，我们总结了对西非不同疟疾易感性的族群进行调查的发现。
