Barzilay J, Heatley G J, Cushing G W
Section of Endocrinology, Lahey Clinic Medical Center, Burlington, Mass 01805.
Arch Intern Med. 1991 Aug;151(8):1629-32.
Growth hormone and its principal mediator insulinlike growth factor I are known promoters of normal growth. To determine whether excessive secretion of growth hormone is associated with an increased occurrence of benign and of malignant tumors, we studied records of 87 patients with acromegaly seen in the Lahey Clinic Medical Center (Burlington, Mass) from 1957 to 1988 and compared the rate of tumor occurrence with a control group of patients with pituitary tumors (198) and with findings from a cancer registry. Patients with acromegaly had a 2.45-fold increased rate of malignant tumors (95% confidence interval, 0.98 to 5.04) compared with findings from the tumor registry. Female patients had a higher rate than male patients. The rate of carcinoma of the thyroid was excessive and previously underscribed, but the rate of carcinoma of the colon was not increased as reported by others. Among benign lesions, goiters, predominantly nodular, were seen in 25% of patients in addition to a large number of mesenchymal lesions.
生长激素及其主要介质胰岛素样生长因子I是正常生长的已知促进因子。为了确定生长激素的过度分泌是否与良性和恶性肿瘤的发生率增加有关，我们研究了1957年至1988年在拉希诊所医疗中心（马萨诸塞州伯灵顿）就诊的87例肢端肥大症患者的记录，并将肿瘤发生率与垂体瘤对照组患者（198例）以及癌症登记处的结果进行了比较。与肿瘤登记处的结果相比，肢端肥大症患者的恶性肿瘤发生率增加了2.45倍（95%置信区间，0.98至5.04）。女性患者的发生率高于男性患者。甲状腺癌的发生率过高且以前描述不足，但结肠癌的发生率并未如其他人所报告的那样增加。在良性病变中，25%的患者出现了主要为结节性的甲状腺肿以及大量间质性病变。
