Suppr超能文献

免疫学与顺势疗法。3. 动物模型的实验研究。

Immunology and homeopathy. 3. Experimental studies on animal models.

机构信息

Department of Scienze Morfologico-Biomediche, University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy.

出版信息

Evid Based Complement Alternat Med. 2006 Jun;3(2):171-86. doi: 10.1093/ecam/nel016. Epub 2006 May 2.

Abstract

A search of the literature and the experiments carried out by the authors of this review show that there are a number of animal models where the effect of homeopathic dilutions or the principles of homeopathic medicine have been tested. The results relate to the immunostimulation by ultralow doses of antigens, the immunological models of the 'simile', the regulation of acute or chronic inflammatory processes and the use of homeopathic medicines in farming. The models utilized by different research groups are extremely etherogeneous and differ as the test medicines, the dilutions and the outcomes are concerned. Some experimental lines, particularly those utilizing mice models of immunomodulation and anti-inflammatory effects of homeopathic complex formulations, give support to a real effect of homeopathic high dilutions in animals, but often these data are of preliminary nature and have not been independently replicated. The evidence emerging from animal models is supporting the traditional 'simile' rule, according to which ultralow doses of compounds, that in high doses are pathogenic, may have paradoxically a protective or curative effect. Despite a few encouraging observational studies, the effectiveness of the homeopathic prevention or therapy of infections in veterinary medicine is not sufficiently supported by randomized and controlled trials.

摘要

通过对文献的检索和本综述作者开展的实验研究显示,存在多种动物模型可以用来检验顺势疗法稀释液的作用或顺势疗法的原理。研究结果涉及超抗原低剂量的免疫刺激、“相似律”的免疫学模型、急性或慢性炎症过程的调控以及顺势疗法药物在畜牧业中的应用。不同研究小组使用的模型差异非常大,无论是在试验药物、稀释度还是在结果方面。一些实验方法,特别是利用免疫调节和顺势疗法复杂配方的抗炎作用的小鼠模型,为顺势疗法高稀释度在动物中产生真实作用提供了支持,但这些数据往往是初步的,尚未得到独立的复制。来自动物模型的证据支持传统的“相似律”,根据该规律,化合物的超低剂量,在高剂量时具有致病性,可能具有矛盾的保护或治疗作用。尽管有一些令人鼓舞的观察性研究,但随机对照试验并没有充分支持顺势疗法在兽医感染预防或治疗中的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cfd/1475939/8d38731cba85/nel016f1.jpg

相似文献

1
Immunology and homeopathy. 3. Experimental studies on animal models.
Evid Based Complement Alternat Med. 2006 Jun;3(2):171-86. doi: 10.1093/ecam/nel016. Epub 2006 May 2.
2
Immunology and homeopathy. 5. The rationale of the 'Simile'.
Evid Based Complement Alternat Med. 2007 Jun;4(2):149-63. doi: 10.1093/ecam/nel117. Epub 2007 Feb 5.
3
High-dilution effects revisited. 2. Pharmacodynamic mechanisms.
Homeopathy. 2014 Jan;103(1):22-43. doi: 10.1016/j.homp.2013.08.002.
4
Homeopathy for treatment of irritable bowel syndrome.
Cochrane Database Syst Rev. 2013 Nov 13(11):CD009710. doi: 10.1002/14651858.CD009710.pub2.
5
Immunology and homeopathy. 2. Cells of the immune system and inflammation.
Evid Based Complement Alternat Med. 2006 Mar;3(1):13-24. doi: 10.1093/ecam/nek018. Epub 2006 Feb 5.
6
Rat models of acute inflammation: a randomized controlled study on the effects of homeopathic remedies.
BMC Complement Altern Med. 2007 Jan 17;7:1. doi: 10.1186/1472-6882-7-1.
7
Recommendations for Designing, Conducting and Reporting Clinical Observational Studies in Homeopathic Veterinary Medicine.
Homeopathy. 2023 Nov;112(4):226-239. doi: 10.1055/s-0043-1760845. Epub 2023 Mar 16.
9
Assays of homeopathic remedies in rodent behavioural and psychopathological models.
Homeopathy. 2009 Oct;98(4):208-27. doi: 10.1016/j.homp.2009.09.005.

引用本文的文献

2
Exploring Possible Mechanisms of Hormesis and Homeopathy in the Light of Nanopharmacology and Ultra-High Dilutions.
Dose Response. 2021 Jun 14;19(2):15593258211022983. doi: 10.1177/15593258211022983. eCollection 2021 Apr-Jun.
4
In vivo efficacy of a biotherapic and eugenol formulation against Rhipicephalus microplus.
Parasitol Res. 2017 Mar;116(3):929-938. doi: 10.1007/s00436-016-5366-x. Epub 2017 Jan 5.
5
Transcriptome Profiling of Wheat Seedlings following Treatment with Ultrahigh Diluted Arsenic Trioxide.
Evid Based Complement Alternat Med. 2014;2014:851263. doi: 10.1155/2014/851263. Epub 2014 Nov 27.
6
Immunomodulation of Homeopathic Thymulin 5CH in a BCG-Induced Granuloma Model.
Evid Based Complement Alternat Med. 2013;2013:686018. doi: 10.1155/2013/686018. Epub 2013 Jan 28.
7
Rats Born to Mothers Treated with Dexamethasone 15 cH Present Changes in Modulation of Inflammatory Process.
Evid Based Complement Alternat Med. 2012;2012:710923. doi: 10.1155/2012/710923. Epub 2012 Jul 29.
8
Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies.
Evid Based Complement Alternat Med. 2012;2012:954374. doi: 10.1155/2012/954374. Epub 2012 Apr 4.
9
Postconditioning hormesis put in perspective: an overview of experimental and clinical studies.
Dose Response. 2011;9(2):209-24. doi: 10.2203/dose-response.10-004.Wiegant. Epub 2010 Aug 12.
10
Inflammatory Process Modulation by Homeopathic Arnica montana 6CH: The Role of Individual Variation.
Evid Based Complement Alternat Med. 2011;2011:917541. doi: 10.1155/2011/917541. Epub 2011 Jan 19.

本文引用的文献

1
Activity and chronopharmacology of very low doses of physiological immune inducers.
Immunol Today. 1985 Aug;6(8):234-5. doi: 10.1016/0167-5699(85)90007-6.
2
Evaluation of isopathic treatment of Salmonella enteritidis in poultry.
Homeopathy. 2006 Apr;95(2):94-7. doi: 10.1016/j.homp.2006.01.007.
3
Immunology and homeopathy. 2. Cells of the immune system and inflammation.
Evid Based Complement Alternat Med. 2006 Mar;3(1):13-24. doi: 10.1093/ecam/nek018. Epub 2006 Feb 5.
4
Immunology and homeopathy. 1. Historical background.
Evid Based Complement Alternat Med. 2005 Dec;2(4):441-52. doi: 10.1093/ecam/neh141.
7
Platelet aggregation in portal hypertension and its modification by ultra-low doses of aspirin.
Pathophysiol Haemost Thromb. 2005;34(1):29-34. doi: 10.1159/000088545.
9
Reduction in the number of infective Trichinella spiralis larvae in mice by use of homeopathic drugs.
Forsch Komplementarmed Klass Naturheilkd. 2005 Aug;12(4):202-5. doi: 10.1159/000086306. Epub 2005 Aug 29.
10
Review of the current involvement of homeopathy in veterinary practice and research.
Vet Rec. 2005 Aug 20;157(8):224-9. doi: 10.1136/vr.157.8.224.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验