Department of Scienze Morfologico-Biomediche, University of Verona, Piazza L.A. Scuro, 37134 Verona, Italy.
Evid Based Complement Alternat Med. 2006 Jun;3(2):171-86. doi: 10.1093/ecam/nel016. Epub 2006 May 2.
A search of the literature and the experiments carried out by the authors of this review show that there are a number of animal models where the effect of homeopathic dilutions or the principles of homeopathic medicine have been tested. The results relate to the immunostimulation by ultralow doses of antigens, the immunological models of the 'simile', the regulation of acute or chronic inflammatory processes and the use of homeopathic medicines in farming. The models utilized by different research groups are extremely etherogeneous and differ as the test medicines, the dilutions and the outcomes are concerned. Some experimental lines, particularly those utilizing mice models of immunomodulation and anti-inflammatory effects of homeopathic complex formulations, give support to a real effect of homeopathic high dilutions in animals, but often these data are of preliminary nature and have not been independently replicated. The evidence emerging from animal models is supporting the traditional 'simile' rule, according to which ultralow doses of compounds, that in high doses are pathogenic, may have paradoxically a protective or curative effect. Despite a few encouraging observational studies, the effectiveness of the homeopathic prevention or therapy of infections in veterinary medicine is not sufficiently supported by randomized and controlled trials.
通过对文献的检索和本综述作者开展的实验研究显示,存在多种动物模型可以用来检验顺势疗法稀释液的作用或顺势疗法的原理。研究结果涉及超抗原低剂量的免疫刺激、“相似律”的免疫学模型、急性或慢性炎症过程的调控以及顺势疗法药物在畜牧业中的应用。不同研究小组使用的模型差异非常大,无论是在试验药物、稀释度还是在结果方面。一些实验方法,特别是利用免疫调节和顺势疗法复杂配方的抗炎作用的小鼠模型,为顺势疗法高稀释度在动物中产生真实作用提供了支持,但这些数据往往是初步的,尚未得到独立的复制。来自动物模型的证据支持传统的“相似律”,根据该规律,化合物的超低剂量,在高剂量时具有致病性,可能具有矛盾的保护或治疗作用。尽管有一些令人鼓舞的观察性研究,但随机对照试验并没有充分支持顺势疗法在兽医感染预防或治疗中的有效性。