Harry G Jean, Lawler Cindy, Brunssen Susan H
Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health/DHHS, Research Triangle Park, NC 27709, USA.
Neurotoxicology. 2006 Sep;27(5):658-70. doi: 10.1016/j.neuro.2006.05.004. Epub 2006 May 17.
Studies examining maternal infection as a risk factor for neurological disorders in the offspring have suggested that altered maternal immune status during pregnancy can be considered as an adverse event in prenatal development. Infection occurring in the mother during the gestational period has been implicated in multiple neurological effects. The current manuscript will consider the issue of immune/inflammatory conditions during prenatal development where adverse outcomes have been linked to maternal systemic infection. The discussions will focus primary on white matter and oligodendrocytes as they have been identified as target processes. This white matter damage occurs in very early preterm infants and in various other human diseases currently being examined for a linkage to maternal or early developmental immune status. The intent is to draw attention to the impact of altered immune status during pregnancy on the offspring for the consideration of such contributing factors to the general assessment of developmental neurotoxicology.
研究将母体感染视为后代神经疾病的一个风险因素，这表明孕期母体免疫状态的改变可被视为产前发育中的不良事件。孕期母亲发生的感染与多种神经影响有关。本手稿将探讨产前发育期间免疫/炎症状况的问题，其中不良后果与母体全身感染有关。讨论将主要集中在白质和少突胶质细胞上，因为它们已被确定为目标过程。这种白质损伤发生在极早早产儿以及目前正在研究与母体或早期发育免疫状态相关联的各种其他人类疾病中。目的是提请关注孕期免疫状态改变对后代的影响，以便在发育神经毒理学的总体评估中考虑这些促成因素。
