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蛋白质缺乏对细胞介导免疫的影响。

The effects of protein deprivation on cell-mediated immunity.

作者信息

Cooper W C, Mariani T N, Good R A

出版信息

Birth Defects Orig Artic Ser. 1975;11(1):223-8.

PMID:167880
Abstract

The effect of protein insufficiency on immune responsiveness was investigated in inbred mice fed isocaloric diets low and normal in protein. Mice were tested for aberrations of cell-mediated and humoral immunities. Protein insufficiency enhances cell-mediated immunity while depressing or not affecting humoral immunity. Cell-mediated immunity was enhanced in testing: allogeneic skin graft rejection, spleen cell responsiveness to phytohemagglutinin, the graft-vs-host reaction, macrophage function, and resistance to viral and bacterial infections.

摘要

在摄入蛋白质含量低和正常的等热量饮食的近交系小鼠中,研究了蛋白质不足对免疫反应性的影响。对小鼠的细胞介导免疫和体液免疫异常进行了检测。蛋白质不足会增强细胞介导免疫,同时抑制或不影响体液免疫。在以下检测中细胞介导免疫增强:同种异体皮肤移植排斥反应、脾细胞对植物血凝素的反应性、移植物抗宿主反应、巨噬细胞功能以及对病毒和细菌感染的抵抗力。

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