膦酰乙酸对蛙病毒3复制的抑制作用。
Phosphonoacetic Acid inhibition of frog virus 3 replication.
作者信息
Elliott R M, Bateson A, Kelly D C
机构信息
Unit of Invertebrate Virology, Natural Environment Research Council, and Department of Forestry, University of Oxford, Oxford, OX1 3UB, United Kingdom.
出版信息
J Virol. 1980 Jan;33(1):539-42. doi: 10.1128/JVI.33.1.539-542.1980.
Phosphonoacetic acid at concentrations above 200 mug/ml inhibited the replication of frog virus 3 in BHK cells. The inhibition of viral DNA replication observed in these cells was reversible and correlated with the inhibition of the virus-induced DNA polymerase activity in an in vitro assay. The synthesis of frog virus 3-induced late or gamma polypeptides was also inhibited by phosphonoacetic acid, although the early (alpha and beta) polypeptides were unaffected.
浓度高于200微克/毫升的膦酰乙酸抑制了青蛙病毒3在BHK细胞中的复制。在这些细胞中观察到的病毒DNA复制抑制是可逆的，并且与体外试验中病毒诱导的DNA聚合酶活性的抑制相关。膦酰乙酸也抑制了青蛙病毒3诱导的晚期或γ多肽的合成，尽管早期（α和β）多肽未受影响。
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