膦甲酸钠对单纯疱疹病毒感染的抑制作用。
Suppression of herpes simplex virus infection by phosphonoacetic acid.
作者信息
Shipkowitz N L, Bower R R, Appell R N, Nordeen C W, Overby L R, Roderick W R, Schleicher J B, Von Esch A M
出版信息
Appl Microbiol. 1973 Sep;26(3):264-7. doi: 10.1128/am.26.3.264-267.1973.
Abstract
Disodium phosphonoacetate when administered orally or topically to mice experimentally infected with herpes simplex virus was able to significantly reduce the mortality associated with the agent. In addition, this compound was able to reduce herpesvirus lesions on the corneas of infected rabbits.
摘要
膦酰乙酸二钠经口服或局部给药于实验感染单纯疱疹病毒的小鼠时，能够显著降低与该病原体相关的死亡率。此外，这种化合物能够减少感染兔子角膜上的疱疹病毒损伤。
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1
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J Infect Dis. 1965 Jun;115:237-46. doi: 10.1093/infdis/115.3.237.
2
Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups.鼻咽癌、其他头颈部肿瘤及对照组中针对EB病毒的抗体。
J Natl Cancer Inst. 1970 Jan;44(1):225-31.
3
The association of herpesvirus type 2 and carcinoma of the uterine cervix.2型疱疹病毒与子宫颈癌的关联。
Am J Epidemiol. 1969 May;89(5):547-54. doi: 10.1093/oxfordjournals.aje.a120967.
4
Common external ocular infections.常见的外部眼部感染。
Postgrad Med. 1969 May;45(5):144-8. doi: 10.1080/00325481.1969.11697135.
5
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