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1
Suppression of herpes simplex virus infection by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒感染的抑制作用。
Appl Microbiol. 1973 Sep;26(3):264-7. doi: 10.1128/am.26.3.264-267.1973.
2
Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.膦甲酸治疗实验性眼部单纯疱疹感染
Antimicrob Agents Chemother. 1976 Feb;9(2):308-11. doi: 10.1128/AAC.9.2.308.
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Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia.膦甲酸钠对感觉神经节单纯疱疹病毒感染的疗效。
Infect Immun. 1976 May;13(5):1519-21. doi: 10.1128/iai.13.5.1519-1521.1976.
4
Phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.膦甲酸治疗实验性单纯疱疹性角膜炎
Antimicrob Agents Chemother. 1975 Mar;7(3):285-8. doi: 10.1128/AAC.7.3.285.
5
Effect of trisodium phosphonoformate and idoxuridine on experimental herpes simplex keratitis in immunized and non-immunized rabbits.膦甲酸钠三钠和碘苷对免疫和未免疫家兔实验性单纯疱疹性角膜炎的影响。
Acta Ophthalmol (Copenh). 1980 Apr;58(2):167-73. doi: 10.1111/j.1755-3768.1980.tb05705.x.
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Limited efficacy of inhibitors of herpes simplex virus DNA synthesis in murine models of recrudescent disease.单纯疱疹病毒DNA合成抑制剂在复发性疾病小鼠模型中的疗效有限。
J Gen Virol. 1988 Jun;69 ( Pt 6):1157-66. doi: 10.1099/0022-1317-69-6-1157.
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Effect of phosphonoacetic acid in the treatment of experimental herpes simplex keratitis.膦甲酸钠治疗实验性单纯疱疹性角膜炎的效果。
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Experimental encephalitis caused by herpes simplex virus: comparison of treatment with tilorone hydrochloride and phosphonoacetic acid.单纯疱疹病毒引起的实验性脑炎：盐酸替洛隆与膦甲酸钠治疗效果比较
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Disodium phosphonoacetate in cream base as a possible topical treatment for skin lesions of herpes simplex virus in cebus monkeys.以乳膏为基质的膦酰乙酸二钠作为卷尾猴单纯疱疹病毒皮肤损伤的一种可能的局部治疗方法。
Antimicrob Agents Chemother. 1977 Oct;12(4):510-2. doi: 10.1128/AAC.12.4.510.

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Approved Antiviral Drugs over the Past 50 Years.过去50年中获批的抗病毒药物。
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Phosphonoacetic Acid inhibition of frog virus 3 replication.膦酰乙酸对蛙病毒3复制的抑制作用。
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Inhibition of herpes simplex virus replication by phosphonoacetic acid.膦甲酸钠对单纯疱疹病毒复制的抑制作用。
Antimicrob Agents Chemother. 1974 Sep;6(3):360-5. doi: 10.1128/AAC.6.3.360.
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Characterization of IM virus, which is frequently isolated from cerebrospinal fluid of patients with multiple sclerosis and other chronic diseases of the central nervous system.IM病毒的特征，该病毒经常从患有多发性硬化症和其他中枢神经系统慢性疾病的患者的脑脊液中分离出来。
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10
In vitro inhibition of Herpesvirus sylvilagus by phosphonoacetic acid and phosphonoformate.膦甲酸钠和膦乙酸对兔疱疹病毒的体外抑制作用。
Arch Virol. 1980;66(3):261-4. doi: 10.1007/BF01314739.

本文引用的文献

1
HERPES SIMPLEX SKIN INFECTION IN MICE.小鼠单纯疱疹皮肤感染
J Infect Dis. 1965 Jun;115:237-46. doi: 10.1093/infdis/115.3.237.
2
Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups.鼻咽癌、其他头颈部肿瘤及对照组中针对EB病毒的抗体。
J Natl Cancer Inst. 1970 Jan;44(1):225-31.
3
The association of herpesvirus type 2 and carcinoma of the uterine cervix.2型疱疹病毒与子宫颈癌的关联。
Am J Epidemiol. 1969 May;89(5):547-54. doi: 10.1093/oxfordjournals.aje.a120967.
4
Common external ocular infections.常见的外部眼部感染。
Postgrad Med. 1969 May;45(5):144-8. doi: 10.1080/00325481.1969.11697135.
5
Cytosine arabinoside therapy for herpes simplex encephalitis--clinical experience with six patients.阿糖胞苷治疗单纯疱疹性脑炎——6例患者的临床经验
Antimicrob Agents Chemother. 1973 Mar;3(3):412-7. doi: 10.1128/AAC.3.3.412.
6
Herpesvirus saimiri malignant lymphoma in spider monkeys. A new susceptible host.蜘蛛猴中的赛米利疱疹病毒恶性淋巴瘤。一种新的易感宿主。
J Med Primatol. 1972;1(2):114-28. doi: 10.1159/000460372.
7
Role of herpesviruses in Marek's disease, a malignant lymphoma of chickens.疱疹病毒在鸡马立克氏病（一种鸡的恶性淋巴瘤）中的作用。
Fed Proc. 1972 Nov-Dec;31(6):1634-8.
8
Peculiarities of the antiviral action of dibenzylphosphinic acid.二苄基次膦酸的抗病毒作用特性
Acta Virol. 1967 May;11(3):199-205.
9
Activity of salicylates as inhibitors of virus replication in vitro and their mode of action.水杨酸盐在体外作为病毒复制抑制剂的活性及其作用方式。
Acta Virol. 1966 May;10(3):185-94.
10
Possible role of Herpesvirus hominis, type 2, in human cervical cancer.人疱疹病毒2型在人类宫颈癌中的可能作用。
Fed Proc. 1972 Nov-Dec;31(6):1651-9.

膦甲酸钠对单纯疱疹病毒感染的抑制作用。

Suppression of herpes simplex virus infection by phosphonoacetic acid.

作者信息

Shipkowitz N L, Bower R R, Appell R N, Nordeen C W, Overby L R, Roderick W R, Schleicher J B, Von Esch A M

出版信息

Appl Microbiol. 1973 Sep;26(3):264-7. doi: 10.1128/am.26.3.264-267.1973.

DOI:10.1128/am.26.3.264-267.1973
PMID:4356456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC379771/
Abstract

Disodium phosphonoacetate when administered orally or topically to mice experimentally infected with herpes simplex virus was able to significantly reduce the mortality associated with the agent. In addition, this compound was able to reduce herpesvirus lesions on the corneas of infected rabbits.

摘要

膦酰乙酸二钠经口服或局部给药于实验感染单纯疱疹病毒的小鼠时，能够显著降低与该病原体相关的死亡率。此外，这种化合物能够减少感染兔子角膜上的疱疹病毒损伤。