人巨细胞病毒。IV. 膦甲酸对病毒诱导的DNA聚合酶活性和病毒DNA复制的特异性抑制作用。
Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid.
作者信息
Huang E S
出版信息
J Virol. 1975 Dec;16(6):1560-5. doi: 10.1128/JVI.16.6.1560-1565.1975.
Abstract
Phosphonoacetic acid specifically inhibited human cytomegalovirus DNA synthesis in virus-infected human fibroblasts as detected by virus-specific nucleic acid hybridization. Inhibition was reversible; viral DNA synthesis resumed upon the removal of the drug. The compound partially inhibited DNA synthesis of host cells in the log phase of growth but had little effect on confluent cells. Studies of partially purified enzymes indicated that phosphonoacetic acid specifically inhibited virus-induced DNA polymerase and had only a slight effect on normal host cell enzymes. The drug was shown to interact directly with virus-induced enzyme but not with the template-primers.
摘要
膦甲酸通过病毒特异性核酸杂交检测，可特异性抑制病毒感染的人成纤维细胞中的人巨细胞病毒DNA合成。抑制作用是可逆的；去除药物后病毒DNA合成恢复。该化合物在对数生长期对宿主细胞的DNA合成有部分抑制作用，但对汇合细胞影响很小。对部分纯化酶的研究表明，膦甲酸特异性抑制病毒诱导的DNA聚合酶，对正常宿主细胞酶只有轻微影响。已证明该药物直接与病毒诱导的酶相互作用，而不与模板引物相互作用。
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