Bloomfield F H, Oliver M H, Harding J E
Liggins Institute, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Arch Dis Child Fetal Neonatal Ed. 2006 Jul;91(4):F299-304. doi: 10.1136/adc.2005.076646.
The immediate prenatal and postnatal consequences of reduced fetal growth have long been known. The longer term associations between reduced birth weight and adult disease risk are also now well established. Reduced fetal growth is usually detected late in gestation, and the assumption has been that this is the time when factors regulating fetal growth have their greatest effect. However, recent evidence suggests that both the growth trajectory of the fetus and its adaptive responses to the prenatal and postnatal environment may be determined in the period around the time of conception.
胎儿生长受限的产前及产后即刻后果早已为人所知。出生体重降低与成人疾病风险之间的长期关联如今也已得到充分证实。胎儿生长受限通常在妊娠晚期才被检测到，人们一直认为这是调节胎儿生长的因素发挥最大作用的时期。然而，最近的证据表明，胎儿的生长轨迹及其对产前和产后环境的适应性反应可能在受孕前后这段时间就已确定。
