早期脓毒症中细胞壁介导的神经元损伤。
Cell wall-mediated neuronal damage in early sepsis.
作者信息
Orihuela Carlos J, Fillon Sophie, Smith-Sielicki S Hope, El Kasmi Karim C, Gao Geli, Soulis Konstantinos, Patil Avinash, Murray Peter J, Tuomanen Elaine I
机构信息
Infectious Diseases, St. Jude Children's Research Hospital, Mailstop 320 IRC 8057, 332 N. Lauderdale Rd., Memphis, TN 38105, USA.
出版信息
Infect Immun. 2006 Jul;74(7):3783-9. doi: 10.1128/IAI.00022-06.
Abstract
Neuronal dysfunction can occur in the course of sepsis without meningitis. Sepsis-associated neuronal damage (SAND) was observed in the hippocampus within hours in experimental pneumococcal bacteremia. Intravascular challenge with purified bacterial cell wall recapitulated SAND. SAND persisted in PAFr(-/-) mice but was partially mitigated in mice lacking cell wall recognition proteins TLR2 and Nod2 and in mice overexpressing interleukin-10 (IL-10) in macrophages. Thus, cell wall drives SAND through IL-10-repressible inflammatory events. Treatment with CDP-choline ameliorated SAND, suggesting that it may be an effective adjunctive therapy to increase survival and reduce organ damage in sepsis.
摘要
在无脑膜炎的脓毒症病程中可发生神经元功能障碍。在实验性肺炎球菌菌血症数小时内，海马体中观察到脓毒症相关神经元损伤（SAND）。用纯化的细菌细胞壁进行血管内攻击可重现SAND。SAND在血小板活化因子受体（PAFr）基因敲除小鼠中持续存在，但在缺乏细胞壁识别蛋白Toll样受体2（TLR2）和核苷酸结合寡聚化结构域蛋白2（Nod2）的小鼠以及巨噬细胞中白细胞介素-10（IL-10）过表达的小鼠中部分减轻。因此，细胞壁通过IL-10可抑制的炎症事件驱动SAND。用胞二磷胆碱治疗可改善SAND，这表明它可能是一种有效的辅助治疗方法，可提高脓毒症患者的生存率并减少器官损伤。
相似文献
1
Cell wall-mediated neuronal damage in early sepsis.早期脓毒症中细胞壁介导的神经元损伤。
Infect Immun. 2006 Jul;74(7):3783-9. doi: 10.1128/IAI.00022-06.
2
[Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice].[Toll样受体2和Toll样受体4参与介导小鼠肺炎球菌感染中的急性中耳炎和死亡率]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
3
Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation.由于细菌清除能力降低和炎症增强，Toll样受体2缺陷型小鼠对肺炎链球菌性脑膜炎高度易感。
J Infect Dis. 2002 Sep 15;186(6):798-806. doi: 10.1086/342845. Epub 2002 Aug 16.
4
Streptococcus pneumoniae: the role of apoptosis in host defense and pathogenesis.肺炎链球菌：细胞凋亡在宿主防御和发病机制中的作用
Int J Biochem Cell Biol. 2006;38(11):1848-54. doi: 10.1016/j.biocel.2006.06.001. Epub 2006 Jun 15.
5
The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis.内皮细胞蛋白C受体削弱小鼠肺炎球菌肺炎和败血症中的抗菌反应。
Thromb Haemost. 2014 May 5;111(5):970-80. doi: 10.1160/TH13-10-0859. Epub 2014 Jan 9.
6
Multifunctional role of choline binding protein G in pneumococcal pathogenesis.胆碱结合蛋白G在肺炎球菌致病机制中的多功能作用
Infect Immun. 2006 Feb;74(2):821-9. doi: 10.1128/IAI.74.2.821-829.2006.
7
Drastic reduction in the virulence of Streptococcus pneumoniae expressing type 2 capsular polysaccharide but lacking choline residues in the cell wall.表达2型荚膜多糖但细胞壁中缺乏胆碱残基的肺炎链球菌毒力急剧降低。
Mol Microbiol. 2006 Apr;60(1):93-107. doi: 10.1111/j.1365-2958.2006.05082.x.
8
TLR2 mediates neuroinflammation and neuronal damage.Toll样受体2介导神经炎症和神经元损伤。
J Immunol. 2007 May 15;178(10):6476-81. doi: 10.4049/jimmunol.178.10.6476.
9
Genetic variants of the MBL2 gene are associated with mortality in pneumococcal sepsis.MBL2 基因的遗传变异与肺炎球菌性败血症患者的死亡率相关。
Diagn Microbiol Infect Dis. 2012 May;73(1):39-44. doi: 10.1016/j.diagmicrobio.2012.02.002.
10
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.血小板活化因子受体与天然免疫：革兰氏阳性菌细胞壁被宿主细胞摄取及细胞特异性病理生理学
J Immunol. 2006 Nov 1;177(9):6182-91. doi: 10.4049/jimmunol.177.9.6182.
引用本文的文献
1
Current Understanding of Long-Term Cognitive Impairment After Sepsis.目前对脓毒症后长期认知障碍的认识。
Front Immunol. 2022 May 6;13:855006. doi: 10.3389/fimmu.2022.855006. eCollection 2022.
2
Perspective of a Pediatrician: Shared Pathogenesis of the Three Most Successful Pathogens of Children.儿科医生视角：儿童期三种最成功病原体的共同发病机制。
Front Cell Infect Microbiol. 2020 Oct 15;10:585791. doi: 10.3389/fcimb.2020.585791. eCollection 2020.
3
Acute Bacterial Meningitis: Challenges to Better Antibiotic Therapy.急性细菌性脑膜炎：优化抗生素治疗面临的挑战
ACS Infect Dis. 2019 Dec 13;5(12):1987-1995. doi: 10.1021/acsinfecdis.9b00122. Epub 2019 Jul 3.
4
: Invasion and Inflammation.: 侵袭与炎症
Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0004-2018.
5
Streptococcus pneumoniae potently induces cell death in mesothelial cells.肺炎链球菌能强烈诱导间皮细胞死亡。
PLoS One. 2018 Jul 30;13(7):e0201530. doi: 10.1371/journal.pone.0201530. eCollection 2018.
6
Magnetic resonance spectroscopy for assessment of brain injury in the rat model of sepsis.磁共振波谱法用于评估脓毒症大鼠模型中的脑损伤
Exp Ther Med. 2017 Nov;14(5):4118-4124. doi: 10.3892/etm.2017.5034. Epub 2017 Aug 25.
7
Preparation of Purified Gram-positive Bacterial Cell Wall and Detection in Placenta and Fetal Tissues.纯化革兰氏阳性菌细胞壁的制备及其在胎盘和胎儿组织中的检测
Bio Protoc. 2016 Dec 5;6(23). doi: 10.21769/BioProtoc.2037.
8
Blood borne: bacterial components in mother's blood influence fetal development.血源性：母亲血液中的细菌成分会影响胎儿发育。
Inflamm Cell Signal. 2016;3(4). doi: 10.14800/ics.1421.
9
Dissecting Bacterial Cell Wall Entry and Signaling in Eukaryotic Cells: an Actin-Dependent Pathway Parallels Platelet-Activating Factor Receptor-Mediated Endocytosis.解析细菌细胞壁进入真核细胞及信号传导：一条依赖肌动蛋白的途径与血小板活化因子受体介导的内吞作用平行。
mBio. 2017 Jan 3;8(1):e02030-16. doi: 10.1128/mBio.02030-16.
10
Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior.细菌肽聚糖穿过胎盘，诱导胎儿神经增殖和产后行为异常。
Cell Host Microbe. 2016 Mar 9;19(3):388-99. doi: 10.1016/j.chom.2016.02.009.
本文引用的文献
1
beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae.β-抑制蛋白1参与肺炎链球菌的血小板活化因子受体介导的内吞作用。
Infect Immun. 2005 Dec;73(12):7827-35. doi: 10.1128/IAI.73.12.7827-7835.2005.
2
Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways.脑内皮细胞的细菌程序性细胞死亡涉及双重死亡途径。
J Clin Invest. 2005 Jun;115(6):1607-15. doi: 10.1172/JCI23223. Epub 2005 May 2.
3
Scope and epidemiology of pediatric sepsis.儿童脓毒症的范围及流行病学
Pediatr Crit Care Med. 2005 May;6(3 Suppl):S3-5. doi: 10.1097/01.PCC.0000161289.22464.C3.
4
Dual phases of apoptosis in pneumococcal meningitis.肺炎球菌性脑膜炎中凋亡的双相阶段。
J Infect Dis. 2004 Dec 1;190(11):2039-46. doi: 10.1086/425520. Epub 2004 Nov 3.
5
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis.胆碱能激动剂可抑制高迁移率族蛋白B1（HMGB1）的释放，并提高实验性脓毒症的存活率。
Nat Med. 2004 Nov;10(11):1216-21. doi: 10.1038/nm1124. Epub 2004 Oct 24.
6
Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain.细菌对磷脂酰胆碱合成的抑制会引发大脑中的细胞凋亡。
J Exp Med. 2004 Jul 5;200(1):99-106. doi: 10.1084/jem.20032100.
7
Therapeutic effects of lysophosphatidylcholine in experimental sepsis.溶血磷脂酰胆碱在实验性脓毒症中的治疗作用
Nat Med. 2004 Feb;10(2):161-7. doi: 10.1038/nm989. Epub 2004 Jan 11.
8
Inflammatory blockade restores adult hippocampal neurogenesis.炎症阻断可恢复成年海马体神经发生。
Science. 2003 Dec 5;302(5651):1760-5. doi: 10.1126/science.1088417. Epub 2003 Nov 13.
9
Role of nod2 in the response of macrophages to toll-like receptor agonists.Nod2在巨噬细胞对Toll样受体激动剂反应中的作用。
Mol Cell Biol. 2003 Nov;23(21):7531-9. doi: 10.1128/MCB.23.21.7531-7539.2003.
10
Innate sensors for Gram-positive bacteria.革兰氏阳性菌的固有传感器。
Curr Opin Immunol. 2003 Aug;15(4):408-15. doi: 10.1016/s0952-7915(03)00078-5.
Zotero 插件