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The animal pathogen-like type III secretion system is required for the intracellular survival of Burkholderia mallei within J774.2 macrophages.动物病原体样III型分泌系统是鼻疽伯克霍尔德菌在J774.2巨噬细胞内存活所必需的。
Infect Immun. 2006 Jul;74(7):4349-53. doi: 10.1128/IAI.01939-05.
2
A disruption of ctpA encoding carboxy-terminal protease attenuates Burkholderia mallei and induces partial protection in CD1 mice.编码羧基末端蛋白酶的ctpA的破坏会减弱鼻疽伯克霍尔德菌，并在CD1小鼠中诱导部分保护作用。
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3
Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice.一种新型鼻疽伯克霍尔德菌毒力因子缺失菌株的表型特征分析，该菌株可对小鼠吸入性鼻疽提供部分保护。
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4
Burkholderia mallei cluster 1 type VI secretion mutants exhibit growth and actin polymerization defects in RAW 264.7 murine macrophages.马鼻疽伯克霍尔德菌簇 1 型 VI 型分泌突变体在 RAW 264.7 鼠巨噬细胞中表现出生长和肌动蛋白聚合缺陷。
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Trans R Soc Trop Med Hyg. 2008 Dec;102 Suppl 1:S127-33. doi: 10.1016/S0035-9203(08)70029-4.
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Type VI secretion is a major virulence determinant in Burkholderia mallei.VI型分泌系统是鼻疽伯克霍尔德菌的主要毒力决定因素。
Mol Microbiol. 2007 Jun;64(6):1466-85. doi: 10.1111/j.1365-2958.2007.05734.x.
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Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages.鼻疽伯克霍尔德菌tssM编码一种假定的去泛素化酶，该酶在被感染的RAW 264.7小鼠巨噬细胞内被分泌并表达。
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The Autotransporter BpaB Contributes to the Virulence of Burkholderia mallei in an Aerosol Model of Infection.自转运蛋白BpaB在气溶胶感染模型中对鼻疽伯克霍尔德菌的毒力有贡献。
PLoS One. 2015 May 20;10(5):e0126437. doi: 10.1371/journal.pone.0126437. eCollection 2015.
9
Novel Burkholderia mallei virulence factors linked to specific host-pathogen protein interactions.新型马鼻疽伯克霍尔德菌毒力因子与特定宿主-病原体蛋白相互作用有关。
Mol Cell Proteomics. 2013 Nov;12(11):3036-51. doi: 10.1074/mcp.M113.029041. Epub 2013 Jun 24.
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DBSecSys 2.0: a database of Burkholderia mallei and Burkholderia pseudomallei secretion systems.DBSecSys 2.0：一个关于鼻疽伯克霍尔德菌和类鼻疽伯克霍尔德菌分泌系统的数据库。
BMC Bioinformatics. 2016 Sep 20;17:387. doi: 10.1186/s12859-016-1242-z.

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Transcriptome analysis of human monocytic cells infected with Burkholderia species and exploration of pentraxin-3 as part of the innate immune response against the organisms.人类单核细胞感染伯克霍尔德菌属物种的转录组分析及五聚蛋白 3 作为固有免疫反应的一部分对抗该生物体。
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3
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4
Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis.巨噬细胞和桔小实蝇感染模型反映了天然存在的类鼻疽伯克霍尔德菌、泰国伯克霍尔德菌和俄克拉荷马伯克霍尔德菌分离株的毒力。
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Identification of Burkholderia mallei and Burkholderia pseudomallei adhesins for human respiratory epithelial cells.鉴定马鼻疽伯克霍尔德菌和类鼻疽伯克霍尔德菌黏附素与人呼吸道上皮细胞的黏附作用。
BMC Microbiol. 2010 Sep 28;10:250. doi: 10.1186/1471-2180-10-250.
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Stable, site-specific fluorescent tagging constructs optimized for burkholderia species.用于伯克霍尔德氏菌属的稳定、定点荧光标记构建体。
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Construction of aminoglycoside-sensitive Burkholderia cenocepacia strains for use in studies of intracellular bacteria with the gentamicin protection assay.构建氨基糖苷类抗生素敏感型洋葱伯克霍尔德氏菌菌株，用于庆大霉素保护试验研究细胞内细菌。
Appl Environ Microbiol. 2010 May;76(10):3170-6. doi: 10.1128/AEM.03024-09. Epub 2010 Mar 26.
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Burkholderia mallei cluster 1 type VI secretion mutants exhibit growth and actin polymerization defects in RAW 264.7 murine macrophages.马鼻疽伯克霍尔德菌簇 1 型 VI 型分泌突变体在 RAW 264.7 鼠巨噬细胞中表现出生长和肌动蛋白聚合缺陷。
Infect Immun. 2010 Jan;78(1):88-99. doi: 10.1128/IAI.00985-09. Epub 2009 Nov 2.
9
Comparison of the in vitro and in vivo susceptibilities of Burkholderia mallei to Ceftazidime and Levofloxacin.鼻疽伯克霍尔德菌对头孢他啶和左氧氟沙星的体外及体内药敏性比较。
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Burkholderia mallei cellular interactions in a respiratory cell model.鼻疽伯克霍尔德菌在呼吸道细胞模型中的细胞相互作用
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本文引用的文献

1
Studies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomallei: II. Virulence and Infectivity for Animals.鼻疽芽生菌和类鼻疽芽生菌某些生物学特性的研究：II. 对动物的毒力和传染性
J Bacteriol. 1948 Jan;55(1):127-35.
2
Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant.来自鼻疽伯克霍尔德菌和泰国伯克霍尔德菌的肌动蛋白结合蛋白可在功能上弥补类鼻疽伯克霍尔德菌bimA突变体基于肌动蛋白的运动缺陷。
J Bacteriol. 2005 Nov;187(22):7857-62. doi: 10.1128/JB.187.22.7857-7862.2005.
3
Multinucleated giant cell formation and apoptosis in infected host cells is mediated by Burkholderia pseudomallei type III secretion protein BipB.感染宿主细胞中多核巨细胞的形成和凋亡是由伯克霍尔德菌Ⅲ型分泌蛋白BipB介导的。
J Bacteriol. 2005 Sep;187(18):6556-60. doi: 10.1128/JB.187.18.6556-6560.2005.
4
Opsonized virulent Brucella abortus replicates within nonacidic, endoplasmic reticulum-negative, LAMP-1-positive phagosomes in human monocytes.调理素化的有毒流产布鲁氏菌在人类单核细胞的非酸性、内质网阴性、LAMP-1阳性吞噬体内复制。
Infect Immun. 2005 Jun;73(6):3702-13. doi: 10.1128/IAI.73.6.3702-3713.2005.
5
Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice.用鼻疽伯克霍尔德菌营养缺陷型菌株进行气溶胶接种可保护小鼠免受气溶胶引发的鼻疽感染。
Vaccine. 2005 Mar 14;23(16):1986-92. doi: 10.1016/j.vaccine.2004.10.017.
6
Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.III型分泌系统簇3是类鼻疽伯克霍尔德菌在仓鼠感染模型中实现最大毒力所必需的。
FEMS Microbiol Lett. 2005 Jan 1;242(1):101-8. doi: 10.1016/j.femsle.2004.10.045.
7
Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis.类鼻疽杆菌bsa III型分泌突变体在类鼻疽病小鼠模型中的减毒毒力和保护效力
Microbiology (Reading). 2004 Aug;150(Pt 8):2669-2676. doi: 10.1099/mic.0.27146-0.
8
Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei.III型分泌系统：一种对鼻疽伯克霍尔德菌致病性至关重要的毒力因子递送系统。
Infect Immun. 2004 Feb;72(2):1150-4. doi: 10.1128/IAI.72.2.1150-1154.2004.
9
A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity.一种伯克霍尔德菌Ⅲ型分泌蛋白BopE，可促进细菌侵袭上皮细胞并具有鸟嘌呤核苷酸交换因子活性。
J Bacteriol. 2003 Aug;185(16):4992-6. doi: 10.1128/JB.185.16.4992-4996.2003.
10
An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen.类鼻疽伯克霍尔德菌中一种类似Inv/Mxi-Spa的III型蛋白分泌系统调节该病原体的细胞内行为。
Mol Microbiol. 2002 Nov;46(3):649-59. doi: 10.1046/j.1365-2958.2002.03190.x.

动物病原体样III型分泌系统是鼻疽伯克霍尔德菌在J774.2巨噬细胞内存活所必需的。

The animal pathogen-like type III secretion system is required for the intracellular survival of Burkholderia mallei within J774.2 macrophages.

作者信息

Ribot Wilson J, Ulrich Ricky L

机构信息

Bacteriology Division, USAMRIID, 1425 Porter St., Fort Detrick, Frederick, MD 21702, USA.

出版信息

Infect Immun. 2006 Jul;74(7):4349-53. doi: 10.1128/IAI.01939-05.

DOI:10.1128/IAI.01939-05
PMID:16790809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1489733/
Abstract

Burkholderia mallei is a highly infectious gram-negative pathogen and is the causative agent of human and animal glanders. By generating polar mutations (disruption of bsaQ and bsaZ) in the B. mallei ATCC 23344 animal pathogen-like type III secretion system (TTS), we demonstrate that this bacterial protein delivery system is required for intracellular growth of B. mallei in J774.2 cells, formation of macrophage membrane protrusions, actin polymerization, and phagosomal escape. These findings suggest that TTS plays a role in the intracellular trafficking of B. mallei and may facilitate cell-to-cell spread via actin-based motility.

摘要

鼻疽伯克霍尔德菌是一种极具传染性的革兰氏阴性病原体，是人类和动物鼻疽病的病原体。通过在鼻疽伯克霍尔德菌ATCC 23344动物病原体样III型分泌系统（TTS）中产生极性突变（bsaQ和bsaZ的破坏），我们证明这种细菌蛋白递送系统是鼻疽伯克霍尔德菌在J774.2细胞内生长、巨噬细胞膜突起形成、肌动蛋白聚合和吞噬体逃逸所必需的。这些发现表明，TTS在鼻疽伯克霍尔德菌的细胞内运输中发挥作用，并可能通过基于肌动蛋白的运动促进细胞间传播。